| 蒋 毅,鲁锦国,王四坤,刘俊辉,方婷婷.原发性高血压患者颈动脉粥样硬化、新发心脑血管事件与幽门螺旋杆菌感染的关系[J].,2019,19(3):511-514 |
| 原发性高血压患者颈动脉粥样硬化、新发心脑血管事件与幽门螺旋杆菌感染的关系 |
| Relationship between Carotid Atherosclerosis, New Cardio Cerebrovascular Events and Helicobacter Pylori Infection in Patients with Primary Hypertension |
| 投稿时间：2018-08-26 修订日期：2018-09-24 |
| DOI：10.13241/j.cnki.pmb.2019.03.026 |
| 中文关键词: 原发性高血压 颈动脉粥样硬化 新发心脑血管事件 幽门螺旋杆菌 感染 关系 |
| 英文关键词: Primary hypertension Carotid atherosclerosis New cardio cerebrovascular events Helicobacter pylori Infection Relationship |
| 基金项目:湖北省卫生厅科研资助项目（JXC1273） |
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| 中文摘要: |
| 摘要 目的：研究原发性高血压（PH）患者颈动脉粥样硬化、新发心脑血管事件与幽门螺旋杆菌（HP）感染的关系。方法：选择从2015年6月到2017年6月在我院接受诊治的PH患者150例纳入本次研究。按照13C尿素呼气试验所测定的HP结果将患者分成HP阳性59例（即超基准值<4.0，记为观察组）和HP阴性91例（即超基准值≥4.0，记为对照组），检测并对比两组血脂指标、超敏C反应蛋白（hs-CRP）、同型半胱氨酸（Hcy）水平以及颈动脉超声检查结果，随访3个月，比较两组新发心脑血管事件。结果：与对照组比较，观察组的低密度脂蛋白型胆固醇（LDL-C）、Hcy及hs-CRP、甘油三酯（TG）、总胆固醇（TC）水平明显升高，高密度脂蛋白型胆固醇（HDL-C）水平明显降低（P<0.05）。观察组CIMT 增厚率为28.82%，形成斑块率为49.15%，均分别高于对照组的15.38%、30.77%，而CIMT正常率为22.03%，明显低于对照组的53.85%，差异均有统计学意义（P<0.05）。观察组新发心脑血管事件的总发生率为13.56%，高于对照组的4.40%，差异有统计学意义（P<0.05）。结论：PH患者的颈动脉粥样硬化、新发心脑血管事件均与HP感染密切相关，临床可考虑清除或预防HP感染，从而科学有效地预防患者的不良预后。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between carotid atherosclerosis, new cardio cerebrovascular events and Helicobacter pylori(HP) infection in patients with primary hypertension (PH). Methods: 150 patients with PH who were treated in our hospital from June 2015 to June 2017 were selected and included in this study. The patient was divided into HP positive with 59 cases (excess reference value <4.0, recorded as observation group) and HP negative with 91 cases (excess reference value ≥4.0, recorded as control group) according to HP results determined by 13C urea breath test. Blood lipids, hypersensitivity C reactive protein (hs-CRP),homocysteine (Hcy) levels and carotid ultrasound examination results were compared between the two groups, and followed up for 3 months, new cardio cerebrovascular events of two groups were compared. Results: Compared with control group, the levels of low density lipoprotein cholesterol (LDL-C), Hcy, hs-CRP, triglyceride (TG), total cholesterol (TC) in the observation group were significantly increased, the high density lipoprotein cholesterol (HDL-C) was significantly decreased (P<0.05). The thickening rate of CIMT in the observation group was 28.82%, and the plaque formation rate was 49.15%, which were respectively significantly higher than 15.38%, 30.77% of the control group, the normal rate of CIMT was 22.03%, which was significantly lower than that of 53.85% in the control group, and the difference was statistically significant (P<0.05). The total incidence rate of new cardio cerebrovascular events in the observation group was 13.56%, which was significantly higher than 4.40% in the control group, the difference was statistically significant (P<0.05). Conclusion: Carotid atherosclerosis and new cardio cerebrovascular events in patients with PH are closely related to HP infection. Clinically, we should consider eliminating or preventing HP infection, so as to prevent the adverse prognosis of patients scientifically and effectively. |
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