文章摘要
李 婷,苏宏伟,刘军超,曹 娟,李 晨,刘 鑫,李向东.乙醛脱氢酶1和肿瘤坏死因子相关诱导凋亡配体在膀胱癌组织中的表达及其临床意义[J].,2019,19(3):498-501
乙醛脱氢酶1和肿瘤坏死因子相关诱导凋亡配体在膀胱癌组织中的表达及其临床意义
Expression of Acetaldehyde Dehydrogenase-1 and Tumor Necrosis Factor-related Apoptosis-inducing Ligand in Bladder Cancer and its Clinical Significance
投稿时间:2018-06-15  修订日期:2018-07-10
DOI:10.13241/j.cnki.pmb.2019.03.023
中文关键词: 膀胱癌  乙醛脱氢酶1  肿瘤坏死因子相关诱导凋亡配体  表达  临床意义
英文关键词: Bladder cancer  Acetaldehyde dehydrogenase-1  Tumor necrosis factor-related apoptosis-inducing ligand  Expression  Clinical significance
基金项目:河北省卫生计生委指令性科研项目(ZL20146301); 张家口市科学技术研究与发展计划项目(1712009D)
作者单位E-mail
李 婷 1 河北北方学院附属第一医院药学部 河北 张家口 0750002 张家口市第二医院药械科 河北 张家口 075100 oeigwe@163.com 
苏宏伟 河北北方学院附属第一医院泌尿外科 河北 张家口 075000  
刘军超 河北北方学院附属第一医院病理科 河北 张家口 075000  
曹 娟 河北北方学院附属第一医院泌尿外科 河北 张家口 075000  
李 晨 河北北方学院附属第一医院泌尿外科 河北 张家口 075000  
刘 鑫 河北北方学院附属第一医院泌尿外科 河北 张家口 075000  
李向东 河北北方学院附属第一医院泌尿外科 河北 张家口 075000  
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中文摘要:
      摘要 目的:探讨乙醛脱氢酶1(ALDH-1)和肿瘤坏死因子相关诱导凋亡配体(TRAIL)在膀胱癌组织中的表达及其临床意义。方法:选取2015年3月到2018年1月在河北北方学院附属第一医院进行治疗的膀胱癌患者70例,收集其手术切除的癌组织和癌旁正常组织,采用免疫组化法检测癌组织和癌旁正常组织中ALDH-1、TRAIL表达情况,分析ALDH-1、TRAIL的表达与膀胱癌患者的临床病理特征的关系及癌组织中ALDH-1、TRAIL表达的相关性。结果:癌组织中的ALDH-1的阳性表达率高于癌旁正常组织,TRAIL的阳性表达率低于癌旁正常组织(P<0.05)。膀胱癌患者的ALDH-1阳性表达率与年龄、性别、分化程度、肿瘤数量无关(P>0.05),临床分期为T2-T3期、有淋巴结转移的膀胱癌患者ALDH-1阳性表达率高于临床分期为Ta-T1期、无淋巴结转移的膀胱癌患者(P<0.05)。膀胱癌患者的TRAIL阳性表达率与年龄、性别、临床分期、淋巴结转移、肿瘤数量无关(P>0.05),高分化的膀胱癌患者TRAIL阳性表达率高于中低分化的膀胱癌患者(P<0.05)。Pearson相关性分析显示,癌组织中ALDH-1、TRAIL表达无明显的相关性(P>0.05)。结论:膀胱癌组织中ALDH-1的表达偏高且与临床分期和淋巴结转移有关,TRAIL的表达偏低且与分化程度有关,但ALDH-1和TRAIL之间无相关性,需进一步探讨与研究。
英文摘要:
      ABSTRACT Objective: To investigate the expression and clinical significance of acetaldehyde dehydrogenase-1 (ALDH-1) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in bladder cancer. Methods: 70 patients with bladder cancer who were treated in First Affiliated Hospital of Hebei North University from March 2015 to January 2018 were selected. The cancer tissues and adjacent normal tissues which were resected in surgical operation were collected. Immunohistochemical method was used to detect the expression of ALDH-1 and TRAIL in cancer tissues and adjacent normal tissues. The relationship between the expression of ALDH-1, TRAIL and the clinicopathological characteristics of bladder cancer and the expression of ALDH-1 and TRAIL in cancer tissues were analyzed. Results: The positive expression rate of ALDH-1 in cancer tissues was higher than that in adjacent normal tissues, and the positive expression rate of TRAIL was lower than that in adjacent normal tissues (P<0.05). The positive expression rate of ALDH-1 in patients with bladder cancer was not related to age, sex, degree of differentiation, and number of tumors(P>0.05). The positive expression rate of ALDH-1 in patients with T2-T3 stage of clinical stage and lymph node metastasis was higher than that of Ta-T1 stage of clinical stage and no lymph node metastasis (P<0.05). The positive expression rate of TRAIL in patients with bladder cancer was not related to age, sex, clinical stage, lymph node metastasis and number of tumors (P>0.05). The positive expression rate of TRAIL in patients with high differentiation was higher than that of middle and low differentiation(P<0.05). Pearson correlation analysis showed that there was no significant correlation between the expression of ALDH-1 and TRAIL in cancer tissues (P>0.05). Conclusion: The expression of ALDH-1 is higher in bladder cancer tissues, and it is correlated with clinical stage and lymph node metastasis. The expression of TRAIL is lower, and it is related to the degree of differentiation. However, there is no correlation between ALDH-1 and TRAIL, which needs urther discussion and research.
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