| 王 科,王琼芬,钟永强,黄 璟,李 曦.炙甘草汤加五参颗粒联合西药治疗冠心病的临床疗效及其对患者血清hs-CRP、NT-proBNP水平和内皮功能的影响[J].,2019,19(3):494-497 |
| 炙甘草汤加五参颗粒联合西药治疗冠心病的临床疗效及其对患者血清hs-CRP、NT-proBNP水平和内皮功能的影响 |
| Clinical Efficacy of Zhigancao Soup and Wushen Granules combined with Western Medicine in the Treatment of Coronary Heart Disease and Its Effect on the Serum hs-CRP, NT-proBNP Levels and Endothelial Function |
| 投稿时间：2018-04-28 修订日期：2018-05-23 |
| DOI：10.13241/j.cnki.pmb.2019.03.022 |
| 中文关键词: 炙甘草汤加五参颗粒剂 冠心病 超敏C反应蛋白 N末端B型脑钠尿肽前体 内皮功能 |
| 英文关键词: Zhigancao Tonga five ginseng granules Coronary heart disease High sensitivity C reactive protein N terminal B type rain natriuretic peptide Endothelial function |
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| 中文摘要: |
| 摘要 目的：探究炙甘草汤加五参颗粒联合西药治疗冠心病的临床疗效及其对患者血清超敏C反应蛋白(hypersensitive C-reactive protein，hs-CRP)、N末端B型脑钠尿肽前体(NT-Pro-brain natriuretic peptide，NT-proBNP)水平和内皮功能的影响。方法：选取2015年12月至2017年10月在我院接受治疗的冠心病患者80例，随机分为观察组和对照组，每组各40例。对照组接受西药治疗，观察组在西药治疗的基础上联合炙甘草汤加五参颗粒治疗。比较两组临床疗效及治疗前后hs-CRP、NT-proBNP、一氧化氮(Nitric oxide，NO)和内皮素(Endothelin-1，ET-1)水平的变化。结果：观察组和对照组治疗后的总有效率分别为90%和72.5%，观察组明显优于对照组(P<0.05)。治疗前，两组血清hs-CRP、NT-proBNP、NO、ET-1水平比较差异无统计学意义(P>0.05)。与同组内治疗前比较，两组治疗后血清NT-proBNP、hs-CRP、ET-1水平均明显下降，血清NO水平均明显升高，且观察组血清NT-proBNP、hs-CRP、ET-1水平均明显低于对照组(P<0.05)，血清NO水平显著高于对照组(P<0.05)。结论：在西药治疗的基础上加用炙甘草汤加五参颗粒治疗冠心病临床疗效明显优于单用西药治疗，可能与其显著降低炎症和改善内皮功能有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical efficacy of Zhigancao soup and Wushen granules combined with western medicine in the treatment of coronary heart disease, and explore the influence on serum hypersensitive C-reactive protein (hs-CRP), N terminal B type natriuretic peptide precursor (NT-proBNP) levels and endothelial function of patients. Methods: Eighty patients with coronary heart disease treated in our hospital from December 2015 to October 2017 were randomly subdivided into the observation group and the control group with 40 cases in each group. The control group was given western medicine treatment, and the observation group was given Zhigancao Tonga Wugang granules treatment on the basis of western medicine treatment. The changes of serum hs-CRP, NT-proBNP, Nitric oxide (NO) and Endothelin-1 (ET-1) before and after treatment were compared between the two groups. Results: The total effective rate of observation group(90%) was obviously superior to that of the control group(72.5%)(P<0.05). Before treatment, there was no significant difference in the levels of serum hs-CRP, NT-proBNP, NO and ET-1 between the two groups (P>0.05). Compared with the group before treatment, the levels of serum NT-proBNP and hs-CRP were significantly decreased and the level of serum NO was significantly increased after treatment in both groups, and the serum levels of NT-proBNP, hs-CRP and ET-1 in the observation group after treatment were significantly lower than those in the control group (P<0.05), while the level of serum NO was significantly higher than that in the control group (P<0.05). Conclusion: Zhigancao Soup and Wushen Granules combined with western medicine is obviously better than western medicine alone in the treatment of coronary heart disease. It may be associated with significant reduce of inflammation and improvement of endothelial function. |
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