文章摘要
徐一凡,徐 武,陈维涛,陆天宇,戴宇翔,梁维邦,金 伟.羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果分析[J].,2019,19(3):454-457
羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果分析
Analysis of the Application Effect of Oxycodone Combined with Dexmedetomidine on the Trigeminal Nerve Microvascular Decompression
投稿时间:2018-05-08  修订日期:2018-05-30
DOI:10.13241/j.cnki.pmb.2019.03.012
中文关键词: 三叉神经微血管减压术  羟考酮  右美托咪定  炎性反应  预后
英文关键词: Trigeminal nerve microvascular decompression  Oxycodone  Dexmedetomidine  Inflammatory response  Prognosis
基金项目:国家自然科学基金面上项目(81171153)
作者单位E-mail
徐一凡 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008 huyanlong79@163.com 
徐 武 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
陈维涛 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
陆天宇 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
戴宇翔 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
梁维邦 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
金 伟 南京大学医学院附属鼓楼医院 神经外科 江苏 南京 210008  
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中文摘要:
      摘要 目的:探讨羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果。方法:选择我院2015年1月~2016年6月收治的86例三叉神经痛患者,按照随机数表法分为对照组和研究组,每组43例。对照组予以羟考酮麻醉,研究组予以羟考酮联合右美托咪定麻醉。比较两组手术前后的血压、平均动脉压、血清白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平的变化,临床疗效、复发情况及不良反应的发生情况。结果:术前,两组血压、平均动脉压、血清CRP、TNF-α比较差异无统计学意义(P>0.05);术后,两组血压、平均动脉压、血清IL-8、CRP、TNF-α水平均较术前下降,且研究组血压、平均动脉压均显著高于对照组,而血清IL-8、CRP、TNF-α水平均明显低于对照组(P<0.05)。两组优良率、复发率比较差异无统计学意义(P>0.05)。两组均有心动过缓、瘙痒、头晕、恶心呕吐发生,但研究组不良反应发生率显著低于对照组(P<0.05)。结论:羟考酮联合右美托咪定在三叉神经微血管减压术中的应用效果确切,能够显著减轻炎症反应,缓解疼痛。
英文摘要:
      ABSTRACT Objective: To analyze the application effect of oxycodone combined with dexmedetomidine on the trigeminal nerve microvascular decompression. Methods: 86 cases of trigeminal neuralgia who were treated from January 2015 to June 2016 in our hospital were selected and divided into the control group and research group with 43 cases in each group according to the random table method. The control group was treated with oxycodone anesthesia, while the research group was treated with oxycodone jiont dexmeidine. Then the blood pressure, mean arterial pressure, serum interleukin-8 (IL-8), c-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) levels before and after the surgery, clinical efficacy, recurrence and adverse reactions were compared between two group. Results: Before surgery, the blood pressure, mean arterial pressure, serum IL-8, CRP, TNF-αshowed no statistically significant difference between the two groups(P>0.05). After surgery, the blood pressure, mean arterial pressure, serum IL-8, CRP, TNF-α in both groups were decreased than those before surgery and the blood pressure, mean arterial pressure of research group were higher than those of the control group, but the serum IL-8, CRP, TNF-αlevels of research group were lower than those of the control group(P<0.05). The excellent rate, recurrence rate of two groups showed no significant difference (P>0.05). There were bradycardia, itching, dizziness, nausea and vomiting in both groups, but the adverse reaction rate in research group was significantly lower than that of the study group(P<0.05). Conclusion: Oxycodone dexmedetomidine was effective in trigeminal nerve microvascular decompression, which could significantly reduce the inflammatory response and relieve the pain.
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