文章摘要
彭玉勃,吴 娇,李 杨,王大利,李小莹,张 艳.大瑶山甜茶正丁醇部位化学成分研究[J].,2019,19(3):434-438
大瑶山甜茶正丁醇部位化学成分研究
Chemical Studies on the n-Butanol Extract of Rubus suavissimus S. Lee
投稿时间:2018-07-30  修订日期:2018-08-24
DOI:10.13241/j.cnki.pmb.2019.03.008
中文关键词: 大瑶山甜茶  正丁醇部位  化学成分
英文关键词: Rubus suavissimus S. Lee  n-Butanol extracts  Chemical compounds
基金项目:国家自然科学基金项目(81274035)
作者单位E-mail
彭玉勃 黑龙江中医药大学佳木斯学院 黑龙江 佳木斯 154007 pengyubohlj@sina.com 
吴 娇 大连民族大学生命科学学院 辽宁 大连 116600  
李 杨 大连民族大学生命科学学院 辽宁 大连 116600  
王大利 大连市儿童医院 辽宁 大连116012  
李小莹 大连民族大学生命科学学院 辽宁 大连 116600  
张 艳 黑龙江中医药大学佳木斯学院 黑龙江 佳木斯 154007  
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中文摘要:
      摘要 目的:研究大瑶山甜茶正丁醇部位中的二萜类化学成分,为探索其活性物质奠定基础。方法:采用95%乙醇提取药材,提取液回收至无醇味后溶于水中,依次用石油醚、乙酸乙酯和正丁醇萃取,减压干燥后获得相应萃取物,综合运用各种色谱技术对正丁醇萃取物进行分离纯化,获取二萜类化合物,通过NMR对得到的化合物进行结构鉴定。结果:从大瑶山甜茶中分离得到10个二萜类化合物,分别鉴定为7β, 17-dihydroxy-16β-ent-kauran-19-oic acid 19-O-β-D-glucopyranoside ester (1), 7β, 17-dihydroxy-ent- kaur-15-en-19-oic acid 19-O-β-D-glucopyranoside ester (2), 13-[(O-β-D-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid 2-O-β-D- glucopyranosyl-β-D-glucopyranosyl ester (3), 12-α-[(2-O-β-D-glucopyranosyl-β-Dglucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D- glucopyranosyl ester (4), glaucocalyxin G (5), β-D-glucopyranosyl 17-hydroxy-ent-kauran-19-oate-16-O-β-D-glucopyranoside (6), cussoracosides E (7), 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (8),cussovantoside A (9),cussovantoside C (10)。结论:化合物1-10首次从大瑶山甜茶中分离得到。
英文摘要:
      ABSTRACT Objective: To study the diterpenoids of n-butanol extract of Rubus suavissimus S. Lee., and to establish the foundation for its active substances. Methods: The medicinal materials were extracted by 95% EtOH. The extract was recovered to non-alcoholic taste and dissolved in water. The extract was successively extracted with petroleum ether, ethyl acetate and n-butanol. After drying under reduced pressure, the corresponding extract was obtained, and the n-butanol extract was separated and purified by various chromatographic techniques. Results: The structures of the compounds were established as 7β, 17-dihydroxy-16β-ent-kauran-19-oic acid 19-O-β-D-glucopyranoside ester (1), 7β, 17-dihydroxy-ent-kaur-15-en-19-oic acid 19-O-β-D-glucopyranoside ester (2), 13-[(O-β-D- glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid 2-O-β-D-glucopyranosyl-β-D-glucopyranosyl ester (3), 12-α-[(2-O-β-D- glucopyranosyl-β- Dglucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester (4), glaucocalyxin G (5), β-D-glucopyranosyl 17-hydroxy- ent-kauran-19-oate-16-O-β-D-glucopyranoside (6), cussoracosides E (7), 17-O-β-D-glucopyranosyl- 16α-ent-kauran-19-oic acid (8), cussovantoside A (9), and cussovantoside C (10). Conclusion: Compounds 1-10 were obtained from Rubus suavissimus S. Lee firstly.
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