| 索晓东,赵 远,王青玲,田 登,胡连训.青海地区献血者HBV感染隐匿风险与基因型分析[J].,2019,19(2):362-365 |
| 青海地区献血者HBV感染隐匿风险与基因型分析 |
| Risk Factors and Genotype Analysis of HBV Occult Infection in the Blood Donors in Qinghai |
| 投稿时间：2018-08-16 修订日期：2018-09-10 |
| DOI：10.13241/j.cnki.pmb.2019.02.036 |
| 中文关键词: 青海地区 献血者 HBV隐匿性感染 基因型 |
| 英文关键词: Qinghai area Blood donors HBV occult infection Genotype |
| 基金项目:青海省重点科技攻关项目(9632009Y0062) |
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| 中文摘要: |
| 摘要 目的：探讨青海地区献血者乙型肝炎病毒(hepatitis b virus，HBV)感染隐匿风险与基因型的相关性。方法：采用回顾性研究方法，选择2014年2月-2018年1月在我院进行无偿献血的青海地区人群750例，采用聚合酶链式反应-限制性内切酶片段法(PCR-RFLP)检测HBV DNA基因的多态性，并进行HBV感染隐匿风险分析。结果：在750例人群中，检出HBV隐匿性感染8例，检出率为1.1%，其中窗口期感染3例，一过性感染5例；基因C型6例，基因B型2例，基因B型患者的都为窗口期感染，核酸定量都≤20 IU/mL，与基因C型患者对比差异有统计学意义(P<0.05)。多因素Logistic回归分析显示基因C型、核酸定量、家属病史、吸烟为导致HBV隐匿性感染的独立危险因素(P<0.05)。结论：青海地区献血者HBV感染隐匿风险相对比较低，多为基因C型，基因C型为导致HBV隐匿性感染的独立危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between the genotype of HBV and occult infection in the blood donors in Qing- hai. Methods: A retrospective study was performed, February 2014 to January 2018, the polymorphism of HBV DNA gene in 750 blood donors from Qinghai were detected by the polymerase chain reaction restriction endonuclease fragment (PCR-RFLP), and the risk of HBV occult infection were analyzed. Results: 8 cases of HBV occult infection were detected in the 750 donors, the detection rate was 1.1%, including 3 cases of window stage infection and 5 cases of transient infection. And there were 6 cases of gene C, 2 cases of gene B type, and genotype B patients were all window stage infection, and the nucleic acid quantity were ≤20 IU/mL, and the difference were statistically significantly compared with genotype C patients(P<0.05). Multivariate Logistic regression analysis showed that genotype C type, nucleic acid quantification, family history and smoking were independent risk factors for HBV occult infection(P<0.05). Conclusion: The risk of HBV occult infection in blood donors in Qinghai is relatively low, and most of them are genotype C, gene C is an independent risk factor for HBV occult infection. |
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