| 孙 凡,刘 恒,徐倩倩,卜 一,马 征.血清MMP-9水平与急性脑梗死溶栓后出血转化的相关性及其预测意义[J].,2019,19(2):350-353 |
| 血清MMP-9水平与急性脑梗死溶栓后出血转化的相关性及其预测意义 |
| Correlation Between Serum MMP-9 Level and Hemorrhage Transformation after Thrombolysis in Acute Cerebral Infarction and its Predictive Significance |
| 投稿时间：2018-03-28 修订日期：2018-04-24 |
| DOI：10.13241/j.cnki.pmb.2019.02.033 |
| 中文关键词: 基质金属蛋白酶-9 急性脑梗死 溶栓 出血转化 相关性 预测意义 |
| 英文关键词: Matrix metalloproteinase-9 Acute cerebral infarction Thrombolysis Hemorrhage transformation Correlation Predic- tive significance |
| 基金项目:河北省卫生厅科研资助项目（20130482）；承德市科学技术研究与发展计划项目（201701A061） |
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| 中文摘要: |
| 摘要 目的：研究血清基质金属蛋白酶-9（MMP-9）水平与急性脑梗死（ACI）溶栓后出血转化（HT）的相关性及其预测意义。方法：选择2014年2月到2017年6月在承德医学院附属医院神经内科诊治的ACI患者130例作为研究对象。根据患者是否存在溶栓后HT将其分成HT组（65例）和NHT组（65例），两组均根据患者的实际病情给予个性化的治疗，对比两组患者实验室指标、血清MMP-9水平、美国国立卫生研究院卒中量表（NIHSS）评分，随访6个月后，记录死亡人数及Barthel指数，并分析患者血清MMP-9水平与其NIHSS评分、Barthel指数、低密度脂蛋白胆固醇（LDL-C）及总胆固醇（TC）水平的相关性。结果：HT组LDL-C及TC水平均低于NHT组（P<0.05）。HT组患者在溶栓前、溶栓后3 d、溶栓后7 d的血清MMP-9水平、NIHSS评分均高于NHT组（P<0.05）。随访6个月后，HT组的死亡率高于NHT组，而Barthel指数低于NHT组（P<0.05）。根据Spearman法分析相关性发现，患者血清MMP-9水平与其NIHSS评分呈正相关，而与Barthel指数、LDL-C及TC水平呈负相关（P<0.05）。结论：血清MMP-9水平与ACI溶栓后HT具有紧密的关联，有助于更好地预测患者的病情及预后，临床上可考虑在治疗ACI溶栓后HT时监测MMP-9水平，从而获得更加精准的辅助性数据参考。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between serum matrix metalloproteinase-9 (MMP-9) level and hemorrhage trans- formation (HT) after thrombolysis in acute cerebral infarction (ACI) and its predictive significance. Methods: 130 patients with ACI who were treated in the Department of Neurology of the Affiliated Hospital of Chengde Medical College from February 2014 to June 2017 were selected as the subjects. According to whether the patients had HT after thrombolysis, they were divided into HT group (65 cases) and NHT group(65 cases), and the two groups were given individualized treatment according to the actual condition of the patient. The laboratory indexes, serum MMP-9 level, National Institutes of Health Stroke Scale(NIHSS) score were compared between the two groups. 6 months after follow-up, the number of deaths and the Barthel index were recorded, and the correlation between serum MMP-9 level and NIHSS score, Barthel index, low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) level were analyzed. Results: The levels of LDL-C and TC in the HT group were significantly lower than the NHT group(P<0.05). The serum MMP-9 level in the HT group before thrombolysis, 3 d after thrombolysis, 7 d after thrombolysis were higher than that in NHT group(P<0.05). At 6 months after follow-up, the mortality rate of HT group was higher than that in NHT group, but the Barthel index was lower than that in NHT group (P<0.05). According to the correlation analysis of Spearman method, it was found that serum MMP-9 level was positively correlated with NIHSS score, but it was negatively correlated with Barthel index, LDL-C and TC levels(P<0.05). Conclusion: Serum MMP-9 level is closely related to HT after thrombolysis in patients with ACI. It helps to better predict the patient's condition and prognosis. It can be con- sidered in clinical treatment of HT after thrombolysis in ACI to monitor MMP-9 level, so as to get more accurate auxiliary data reference. |
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