| 薛天慧,崔美琦,游俊浩,刘 辉,李 方,颜 兵.海南部分地区与省外非转移性浸润性乳腺癌患者临床病理参数的对比分析[J].,2019,19(2):312-316 |
| 海南部分地区与省外非转移性浸润性乳腺癌患者临床病理参数的对比分析 |
| Comparison of the Clinicopathological Parameters of Non-metastatic Invasive Breast Cancer Patients in and out of Hainan Province |
| 投稿时间：2018-03-23 修订日期：2018-04-18 |
| DOI：10.13241/j.cnki.pmb.2019.02.024 |
| 中文关键词: 海南省 乳腺癌 活检淋巴结数 绝经 体重指数 |
| 英文关键词: Hainan province Breast cancer Resected Lymph Nodes Menopause Body Mass Index |
| 基金项目:国家自然科学基金项目（81503391）；海南省自然科学基金面上项目（817392）；三亚市医疗卫生创新项目（2016YW08，2018YW06） |
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| 中文摘要: |
| 摘要 目的：分析海南部分地区(省内)与省外非转移性浸润性乳腺癌患者临床病理参数的异同。方法：收集我院自2012年6月-2017年6月经病理和影像学确诊的非转移性浸润性乳腺癌患者214例，筛选有效病例159例，将患者年龄、肿瘤位置、Scarff Bloom and Richardson(SBR)分级、肿瘤标记物(CEA、CA125、CA153)、TNM分期、阳性/活检淋巴结数、lunimal分型、初潮年龄、绝经状态、生育子女数、体重指数、体表面积等数据按省内、省外进行统计分析。结果：①省内患者确诊年龄明显早于省外(47.48±10.05 vs 51.33±10.03，p=0.02)；②省内患者具有生育子女数较多(1.93±0.97 vs 1.38±0.64，p=0.00)和活检淋巴结数较多(20.67±9.56 vs 18.00±6.74，p=0.04)的特征；③省内患者绝经后体重指数(22.66±3.24 vs 25.56±3.67，p=0.00)和体表面积(1.60±0.12 vs 1.68±0.16，p=0.00)较绝经前明显上升，而省外患者此现象不明显。结论：海南部分地区非转移性浸润性乳腺癌患者具有发病年龄早等特点，绝经后体质改变可能为该地区乳腺癌的促发因素。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the clinicopathological parameters of non-metastatic invasive breast cancer patients in and out of Hainan province. Methods: 214 patients were reviewed and 159 validated cases who were diagnosed by pathological and imageologi- cal examination in our hospital from Jun 2012 to June 2017 were under estimation, parameters including age, tumor location, Scarff Bloom and Richardson (SBR) stage, tumor markers (CEA, CA125, CA153), TNM stages, positive/resected lymph nodes, luminal style, menarche age, menopausal status, children number, body mass index (BMI), body surface area (BSA) were registered and compared be- tween patients in and out of the province. Results: ①patients were much more younger at diagnosis in Hainan province than that from outside(47.48±10.05 vs 51.33±10.03, p=0.02); ②patients in Hainan province were featured by have more children(1.93±0.97 vs 1.38±0.64, p=0.00) and with more resected lymph nodes (20.67±9.56 vs 18.00±6.74, p=0.04), no other significant statistical differ- ences were detected in the rest clinicopathological parameters; ③the BMI (22.66±3.24 vs 25.56±3.67, p=0.00) and BSA (1.60±0.12 vs 1.68±0.16, p=0.00) displayed a significant increasing in postmenopausal patients in Hainan province, no such differences were de- tected in cases from outside. Conclusion: Non-metastatic invasive breast cancer patients in Hainan province were younger, post- menopausal physical change would have an important role in triggering breast cancer. |
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