| 赵 营,赵光日,吴蕴瑜,吕晓刚,杜佩妍.循环肿瘤细胞水平与卵巢癌患者临床病理特征及生存率的关系研究[J].,2019,19(2):290-294 |
| 循环肿瘤细胞水平与卵巢癌患者临床病理特征及生存率的关系研究 |
| The Relationship Research between the Level of Circulating Tumor Cells and the Clinicopathological Features and Survival Rate of Ovarian Cancer Patients |
| 投稿时间：2018-04-17 修订日期：2018-05-13 |
| DOI：10.13241/j.cnki.pmb.2019.02.019 |
| 中文关键词: 循环肿瘤细胞 卵巢癌 临床病理特征 生存率 关系 |
| 英文关键词: Circulating tumor cell Ovarian cancer Clinicopathological features Survival rate Relationship |
| 基金项目:广东省医学科研基金项目（B20150152） |
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| 中文摘要: |
| 摘要 目的：研究循环肿瘤细胞（CTC）水平与卵巢癌患者临床病理特征及生存率的关系。方法：选择从2012年6月到2014年12月在我院就诊的卵巢癌患者94例记为观察组。根据所有患者CTC水平将其分成高CTC组（CTC水平≥7个/5mL）57例及低CTC组（CTC水平<7个/5 mL）37例，另选同期在我院体检的卵巢良性囊肿者90例记为对照组，分析CTC阳性与患者病理特征的关系、CTC水平与患者生存率和复发转移的关系以及CTC水平与患者病理特征、生存率、复发转移率的相关性。结果：对照组90例患者均未检测出CTC阳性。观察组94例患者中检测出68例CTC阳性，总阳性率为72.34%；观察组患者临床分期为II期和III期的CTC阳性率均明显高于I期，有淋巴结转移的CTC阳性率明显高于无淋巴结转移（P<0.05）。高CTC组的1年、2年、3年生存率与低CTC组相比，差异均无统计学意义（P>0.05）。高CTC组的1年、2年、3年复发转移率均高于低CTC组（P<0.05）。Spearman相关性分析结果显示，CTC水平与患者的临床分期、淋巴结转移以及复发转移率均呈正相关（P<0.05），而与年龄、病理分型、病理分级及生存率均无明显相关性（P>0.05）。结论：卵巢癌患者临床分期为Ⅱ期和Ⅲ期和有淋巴结转移的CTC阳性率较高，且CTC水平与复发转移率关系密切，临床通过检测CTC水平，可能有助于评估患者的预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the level of circulating tumor cell (CTC) and the clinicopathological features and survival rate of ovarian cancer patients. Methods: 94 patients with ovarian cancer who were treated in our hospital from June 2012 to December 2014 were enrolled in this study as observation group. The patients were divided into high CTC group (CTC level≥7 cases/5 mL) with 57 cases and low CTC group (CTC level<7 cases/5 mL) with 37 cases according to CTC level, another 90 patients with benign ovarian cysts who were examinated in our hospital were enrolled as control group at the same time, the relationship between CTC positive and pathological features, the relationship between CTC level and survival rate, recurrence and metastasis rate, and the correlation between CTC level and pathological features, survival rate, recurrence and metastasis rate of patients were analyzed. Results: 90 patients in the control group were not detected positive for CTC, 68 cases of the 94 patients in the observation group were detected positive for CTC, and the total positive rate was 72.34%. The positive rate of CTC in stage II and stage III of the observation group were significantly higher than that in stage I, the positive rate of CTC in lymph node metastasis was significantly higher than that without lymph node metastasis(P<0.05).The 1 year, 2 years, 3 years survival rate in the high CTC group was not significantly different from that in the low CTC group(P>0.05). The 1 year, 2 years, 3 years rate of recurrence and metastasis in the high CTC group was significantly higher than that in the low CTC group(P<0.05). According to the method of Spearman correlation analysis showed that the level of CTC in patients with clinical stage, lymph node metastasis and recurrence rate were positively correlated(P<0.05), but not significantly correlated with age, pathological type, pathological grading and survival rate(P>0.05). Conclusion: The positive rate of CTC in stage II and stage III, with lymph node metastasis of ovarian cancer patients is high, and the level of CTC is closely related to the recurrence and metastasis rate. Clinical detection of CTC level may help to evaluate the prognosis of patients. |
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