| 丁 雷,董笑克,郭翔宇,刘铜华,段 颖,孙 文,韩亦凡,乐海波.糖尿病肾病啮齿动物模型研究进展*[J].,2019,19(1):189-192 |
| 糖尿病肾病啮齿动物模型研究进展* |
| Research Progress of DN (Diabetic Nephropathy) Rodent Model* |
| 投稿时间：2018-02-27 修订日期：2018-03-23 |
| DOI：10.13241/j.cnki.pmb.2019.01.041 |
| 中文关键词: 糖尿病肾病 动物模型 综述 |
| 英文关键词: Diabetic nephropathy Rodent Animal model Review |
| 基金项目:北京中医药大学东方医院东方新星项目（DFRC2014C06）；国家自然科学基金项目（81303130） |
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| 中文摘要: |
| 摘要：糖尿病肾病( Diabetic nephropathy，DN),是糖尿病微血管病变中常见的并发症，也是发展为终末期肾病（End stage renal disease，ESRD）的主要原因之一，其病因与发病机制非常复杂，至今尚未完全阐明。理想的动物模型研究对于探索DN的病因、发病机制，发病早期作出诊断、发现临床相关治疗靶点并探索新的治疗方法，评价干预措施等方面有着不可替代的作用。本文现就目前国内外常用的DN 啮齿动物模型展开综述，探讨不同DN啮齿动物模型的特点和应用范围。 |
| 英文摘要: |
| ABSTRACT: Diabetic nephropathy (DN) is a common complication in diabetic microangiopathy and is one of the main causes of end stage renal disease (ESRD). Its etiology and pathogenesis are very complicated, and they have not been fully elucidated. The ideal animal model study can help to explore the etiology and pathogenesis of DN, to diagnose early onset, to find clinically relevant therapeutic targets and to explore new treatment methods, evaluation of interventions and other aspects of irreplaceable role. In this paper, we present a review of the commonly used DN rodent models at home and abroad to explore the characteristics and application of different DN rodent models. |
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