| 杨 敬,郑 劲,钟 锦,刘承玄,任德伟.百令胶囊联合左卡尼汀对维持性血液透析患者氧化应激、T淋巴细胞亚群及营养状态的影响*[J].,2019,19(1):145-149 |
| 百令胶囊联合左卡尼汀对维持性血液透析患者氧化应激、T淋巴细胞亚群及营养状态的影响* |
| Effects of Bailing Capsule Combined with Levocarnitine on Oxidative Stress,T Lymphocyte Subsets and Nutritional Status in Patients with Maintenance Hemodialysis* |
| 投稿时间：2018-03-28 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2019.01.032 |
| 中文关键词: 百令胶囊 左卡尼汀 维持性血液透析 氧化应激 T淋巴细胞亚群 营养状态 |
| 英文关键词: Bailing capsule Levocarnitine Maintenance hemodialysis Oxidative stress T lymphocyte subsets Nutritional status |
| 基金项目:重庆市卫计委科技项目（ZY20150235） |
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| 中文摘要: |
| 摘要 目的：探讨百令胶囊联合左卡尼汀对维持性血液透析（MHD）患者氧化应激、T淋巴细胞亚群及营养状态的影响。方法：选取我院于2015年6月至2017年4月期间接受MHD治疗的慢性肾衰竭患者72例为研究对象。按照数表法将患者随机分为对照组（n=36）和实验组（n=36）。两组患者均行MHD治疗，实验组患者在此基础上给予百令胶囊联合左卡尼汀治疗，疗程均为6个月。比较两组治疗前、治疗6个月后的氧化应激指标：血浆丙二醛（MDA）、血浆谷胱甘肽过氧化物酶（GSHPx）、血浆总高半胱氨酸（tHcy）水平，免疫功能指标：CD3+、CD4+、CD8+、CD4+/CD8+，营养状态指标：血红蛋白（Hb）、白蛋白（Alb）、前白蛋白（PA）、总胆固醇（TCh）、三酰甘油（TG）、脂蛋白（a）[Lp（a）]。结果：两组患者治疗6个月后MDA、tHcy水平下降，且实验组低于对照组（P<0.05）；治疗6个月后实验组患者GSHPx水平高于治疗前与对照组（P<0.05），而对照组GSHPx水平与治疗前相比差异无统计学意义（P>0.05）。治疗6个月后，实验组患者CD3+、CD4+、CD4+/CD8+水平高于治疗前及对照组，而CD8+低于治疗前及对照组（P<0.05）。实验组治疗6个月后Hb、Alb、PA水平高于治疗前及对照组，而Lp（a）低于治疗前及对照组（P<0.05），实验组患者TCh、TG水平与治疗前比较差异无统计学意义（P>0.05）；对照组治疗6个月后Hb、Alb、PA、TCh、TG、Lp（a）水平与治疗前比较差异均无统计学意义（P>0.05）。结论：百令胶囊联合左卡尼汀可减轻MHD患者氧化应激反应，调节T淋巴细胞亚群，同时改善患者营养状况，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Bailing Capsule Combined with Levocarnitine on oxidative stress,T lymphocyte subsets and nutritional status in patients with maintenance hemodialysis(MHD). Methods: 72 patients with chronic renal failure treated with MHD in our hospital from June 2015 to April 2017 were selected as the subjects. The patients were randomly divided into control group (n=36) and experimental group (n=36) in accordance with the number table method. The two groups were treated with MHD, the experimental group were given Bailing Capsule combined with Levocarnitine on this basis, the course of treatment was 6 months. Oxidative stress indicators: plasma malondialdehyde (MDA), plasma glutathione peroxidase (GSHPx), plasma total homocysteine (tHcy) level, Immune function indicators: CD3+, CD4+, CD8++ and CD4+/CD8+, nutritional status indicators: hemoglobin (Hb), albumin (Alb), prealbumin (PA), total cholesterol (TCh), three acylglycerol (TG), lipoprotein (a) [Lp (a)] were compared before and 6 months after treatment. Results: The levels of MDA and tHcy decreased 6 months after treatment in the two groups,and the experimental group was lower than that of the control group (P<0.05). The level of GSHPx in the experimental group 6 months after treatment was higher than that before the treatment and the control group (P<0.05). There was no significant difference in the level of GSHPx in the control group compared with that before the treatment (P>0.05). The level of CD3+, CD4+ and CD4+/CD8+ in the experimental group 6 months after treatment was higher than before reatment and the control group,while the CD8+ was lower than that before treatment and the control group (P<0.05). The level of Hb, Alb and PA in the experimental group 6 months after treatment were higher than before treatment and the control group, while the Lp (a) was lower than before treatment and the control group (P<0.05). There was no significant difference in the level of TCh and TG between the patients in the experimental group and before treatment (P>0.05). There was no significant difference in the level of Hb, Alb, PA, TCh, TG, Lp (a) after 6 months of treatment in the control group compared with before treatment (P>0.05). Conclusion: Bailing Capsule Combined with L-carnitine can alleviate oxidative stress in patients with MHD, the regulation of T lymphocyte subsets, and improve the nutritional status of the patients, it is worthy of clinical application. |
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