| 侯婷婷,侯 惺,李 远,李 钿,索海燕.血清25-羟维生素D水平与脓毒症患儿凝血功能、炎性因子及预后的关系*[J].,2019,19(1):141-144 |
| 血清25-羟维生素D水平与脓毒症患儿凝血功能、炎性因子及预后的关系* |
| The Relationship between Serum 25-hydroxyvitamin D Level and Coagulation Function, in Flammatory Factors and Prognosis in Children with Sepsis* |
| 投稿时间：2018-04-17 修订日期：2018-05-13 |
| DOI：10.13241/j.cnki.pmb.2019.01.031 |
| 中文关键词: 脓毒症 25-羟维生素D 凝血功能 预后 炎性因子 相关性 |
| 英文关键词: Sepsis 25-hydroxyvitamin D Coagulation function Prognosis Inflammatory factor Correlation |
| 基金项目:山东省科技发展计划项目(2012GGB1531) |
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| 中文摘要: |
| 摘要 目的：探讨血清25-羟维生素D（25-OH-VitD）水平与脓毒症患儿凝血功能、炎性因子及预后的相关性。方法：选取2016年5月-2017年12月期间山东省立医院收治的脓毒症患儿68例为研究组，根据研究组患儿血清25-OH-VitD水平将其分为三组：缺乏组（<20 ng/mL）6例、不足组（20-29.9 ng/mL）19例、充足组（≥30 ng/mL）43例，再根据研究组患儿28d后转归情况分为好转组56例与恶化组12例。另选取同时期在山东省立医院进行体检的健康儿童46例为对照组，检测并比较各组实验室指标，并分析血清25-OH-VitD与C反应蛋白（CRP）、白介素-2R（IL-2R）、白介素-6（IL-6）、降钙素原（PCT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）的相关性，对脓毒症患儿预后的独立影响因素进行Logistic回归分析。结果：缺乏组、不足组、充足组患儿CRP、IL-2R、IL-6、PCT、PT、APTT水平均明显高于对照组（P<0.05），其中CRP、IL-2R、IL-6、PCT随着25-OH-VitD水平的降低而升高（P<0.05）。与恶化组对比，好转组患儿血清25-OH-VitD水平明显升高，CRP、IL-2R、IL-6、PCT水平明显降低（P<0.05）。经Pearson相关性分析显示，脓毒症患儿血清25-OH-VitD均与CRP、IL-2R、IL-6、PCT呈负相关（P<0.05），与PT、APTT无关（P>0.05）。经Logistic回归分析显示，血清25-OH-VitD是脓毒症患儿预后的独立影响因素（P<0.05）。结论：血清25-OH-VitD与脓毒症患儿炎性因子密切相关，与凝血功能指标无关，且血清25-OH-VitD是其预后的独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum 25-hydroxyvitamin D (25-OH-VitD), coagulation function,inflammatory factors and prognosis in children with sepsis. Methods: 68 children with sepsis who were treated in Shandong Provincial Hospital from May 2016 to December 2017 were selected as the study group. According to the serum 25-OH-VitD level of the children in the study group, it was divided into three groups: 6 cases of lack group (<20 ng/mL), 19 cases of insufficient group (20-29.9 ng/mL), 43 cases of adequate group (more than 30 ng/mL). According to the prognosis of 28d in the study group, the patients was divided into 56 cases in the improvement group and 12 cases in the worsening group. 46 healthy children selected for physical examination in Shandong Provincial Hospital in the same period as the control group. The laboratory indexes of each group were detected and compared. The correlation between serum 25-OH-VitD, C reactive protein (CRP), interleukin-2R (IL-2R), interleukin-6 (IL-6), procalcitonin (PCT),prothrombin time (PT), activated partial thromboplastin time (APTT) were analyzed.Logistic regression analysis was conducted on the independent prognostic factors of children with sepsis. Results: The levels of CRP, IL-2R, IL-6, PCT, PT and APTT in the lack group,the insufficient group and the adequate group were all significantly higher than those of the control group (P<0.05). CRP, IL-2R, IL-6 and PCT increased with the decrease of 25-OH-VitD level (P<0.05). Compared with the worsening group, the serum 25-OH-VitD level of the children in the improvement group was significantly increased, and the levels of CRP, IL-2R, IL-6 and PCT were significantly decreased (P<0.05). The Pearson correlation analysis showed that the serum 25-OH-VitD of children with sepsis was negatively correlated with CRP, IL-2R, IL-6 and PCT (P<0.05), it has no correlation with PT and APTT(P>0.05). Logistic regression analysis showed that serum 25-OH-VitD was independent factor affecting the prognosis of children with sepsis（P<0.05）. Conclusion: Serum 25-OH-VitD is closely related to inflammatory factors in children with sepsis, it is not related to the indexes of coagulation function, and serum 25-OH-VitD is an independent prognostic factor. |
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