| 宋 强,谢学刚,胡 志,王宇星,薛建颖.参松养心胶囊对心房颤动患者P波离散度及血清炎性因子水平的影响*[J].,2019,19(1):91-94 |
| 参松养心胶囊对心房颤动患者P波离散度及血清炎性因子水平的影响* |
| Effect of Shensong Yangxin Capsule on P Wave Dispersion and Serum Inflammatory Factors in Patients with Atrial Fibrillation* |
| 投稿时间：2018-05-14 修订日期：2018-06-10 |
| DOI：10.13241/j.cnki.pmb.2019.01.019 |
| 中文关键词: 参松养心胶囊 心房颤动 P波离散度 炎性因子 疗效 |
| 英文关键词: Shensong Yangxin Capsule Atrial fibrillation P wave dispersion Inflammatory factors Curative effect |
| 基金项目:陕西省社会发展科技攻关基金项目（2015FS483） |
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| 中文摘要: |
| 摘要 目的：探讨参松养心胶囊对心房颤动（AF）患者P波离散度（Pd）及血清炎性因子水平的影响，为临床用药提供依据。方法：将西安交通大学第一附属医院2016年3月-2018年1月收治的AF患者纳入本研究，共148例。所有患者根据不同的治疗方式分为对照组和观察组。对照组（n=74）接受常规治疗，观察组（n=74）在对照组基础上加用参松养心胶囊，两组均治疗8周。比较两组患者治疗后的临床疗效，观察并比较两组患者治疗前及治疗后的Pd、最大P波时限（Pmax）变化情况，检测两组患者治疗前及治疗后的血清炎性因子水平，记录不良反应发生情况。结果：观察组总有效率为89.19%（66/74），高于对照组的70.27%（52/74）（P<0.05）。两组患者治疗后的Pmax、Pd均明显降低，且观察组患者治疗后的Pmax、Pd均明显低于对照组（P<0.05）。两组患者治疗后的血清炎性因子水平均明显降低，且与对照组相比，观察组患者治疗后的血清肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）、白介素-6（IL-6）水平均降低（P<0.05）。两组不良反应发生情况比较无统计学差异（P>0.05）。结论：参松养心胶囊治疗AF患者安全有效，能明显减轻炎性反应，改善患者心功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Shensong Yangxin Capsule on the levels of P wave dispersion (Pd) and serum inflammatory factors in patients with atrial fibrillation (AF), and to provide a basis for clinical medication. Methods: 148 cases of AF patients who received treatment in the First Affiliated Hospital of Xi'an Jiao Tong University from March 2016 to January 2018 were included in the study. There were 148 cases. All patients were divided into control group and observation group according to different treatment methods. The control group (n=74) received routine treatment, while the observation group (n=74) was additionally treated with Shensong Yangxin Capsule on the basis of the control group. The two groups were treated for 8 weeks. The efficacy of the two groups was compared after treatment. The changes of Pd, maximum P wave time (Pmax) of the two groups were observed before and after treatment. The levels of serum inflammatory factors of the two groups were detected before and after treatment. The adverse reactions of the two groups were recorded. Results: The total effective rate of the observation group was 89.19%(66/74), which was significantly higher than 70.27%(52/74) of the control group (P<0.05). The Pmax and Pd of the two groups were significantly lower after treatment, and the Pmax and Pd in the observation group were significantly lower than those in the control group (P<0.05). And compared with the control group, the levels of serum inflammatory factors in the two groups were significantly lower after treatment. And the levels of serum tumor necrosis factor-α (TNF-α), high sensitive C reactive protein (hs-CRP), interleukin-6 (IL-6) in the observation group were significantly lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Shensong Yangxin Capsule is safe and effective in the treatment of AF patients.It can obviously reduce inflammatory reaction and improve cardiac function of patients. |
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