| 朱珊珊,石晴晴,张 锋,李 强,芦 博.右美托咪啶对经尿道前列腺电切阴茎勃起的影响*[J].,2019,19(1):87-90 |
| 右美托咪啶对经尿道前列腺电切阴茎勃起的影响* |
| Effect of Dexmedetomidine on the Penile Erection of Transurethral Prostate* |
| 投稿时间：2018-05-07 修订日期：2018-05-27 |
| DOI：10.13241/j.cnki.pmb.2019.01.018 |
| 中文关键词: 右美托咪定 经尿道前列腺电切术 前列腺增生 |
| 英文关键词: Dexmedetomidine Transurethral resection of the prostate Benign prostatic hyperplasia |
| 基金项目:国家自然科学基金项目（51275514） |
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| 中文摘要: |
| 摘要 目的：探究右美托咪定(DEX)对经尿道前列腺电切术(TURP)后阴茎勃起的影响。方法：选取2017年1月至2018年3月于我院确诊为良性前列腺增生并行经TURP的86例患者，按照随机数字表法均分为实验组和对照组，每组43例。其中，实验组于手术初始即使用输液泵持续输注右美托咪定(输注剂量0.5 μg/kg)直至手术结束，对照组患者于手术开始时即开始使用输液泵持续输注等量的生理盐水直至手术结束。于麻醉前(T1)、麻醉插管后导尿前(T2)、DEX或生理盐水泵入10 min时(T3)、手术开始后导尿时(T4)四个时间点比较两组患者的平均脉压差(MAP)、心率(HR)、阴茎勃起发生率及术后膀胱刺激征的发生率。结果：T1、T2、T3时刻，两组间HR和MAP水平比较差异无统计学意义(P>0.05)，T4时，对照组HR和MAP均选择低于实验组，差异具有统计学意义(P<0.05)；两组患者T1及T2时阴茎勃起率比较差异无统计学意义(P>0.05)，对照组T3、T4阴茎勃起率分别为27.91%、74.42%，实验组患者T3、T4阴茎勃起率分别为6.98%、11.63%，差异具有统计学意义(P<0.05)。实验组术后膀胱刺激征出现率为9.30%，低于对照组的32.56%，差异具有统计学意义(P<0.05)。结论：右美托咪定用于TURP术中可以有效稳定患者术中血流动力学，并降低患者术后阴茎异常勃起率，且术后患者膀胱刺激征发生率显著降低。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of dexmedetomidine (DEX) on the penile erection after transurethral resection of the prostate (TURP). Methods: From January 2017 to March 2018, 86 cases of patients with benign prostatic hyperplasia treated by TURP in our hospital were selected and divided into the experimental group and the control group according to the random number table, with 43 cases in each group. At the beginning of the operation, the patients in the control group was given continuous infusion with dexmedetomidine by infusion (infusion dose 0.5 μg·kg-1·h-1) until the end of operation. While the same amount of saline was given to the control group. Then the mean pulse pressure (MAP), heart rate (HR) and penile erection rate were compared between two groups before anesthesia (T1), anesthesia after catheterization (T2), DEX or saline pump 10 min (T3), after the start of surgery catheterization. Meanwhile, the incidence of postoperative bladder irritation was compared between two groups. Results: The HR and MAP at T1, T2 and T3 showed no significantly difference between the two groups(P>0.05). The HR and MAP of control group at T4 were lower than those of the experimental group (P< 0.05). There was no significant difference in the penile erection rate between the two groups at T1 and T2 (P>0.05). The penile erection rates at T3 and T4 in control group were 27.91% and 74.42% (6.98%, 11.63%), the difference was statistically significant (P<0.05). The incidence of postoperative bladder irritation in the experimental group was 9.30 %, which was lower than that in the control group (32.56%)(P<0.05). Conclusion: Dexmedetomidine could significantly stabilize the intraoperative hemodynamics and reduce the incidence of postoperative priapism and bladder irritation in the treatment of patients with TURP. |
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