| 杨 林,张晓雨,庄海文,赵海剑,平 洪.术前新辅助放化疗联合全直肠系膜切除术治疗局部进展期直肠癌的疗效观察[J].,2018,(24):4760-4763 |
| 术前新辅助放化疗联合全直肠系膜切除术治疗局部进展期直肠癌的疗效观察 |
| Curative Effect Observation of Preoperative Neoadjuvant Chemoradiotherapy Combined with Total Mesorectal Excision for Locally Advanced Rectal Cancer |
| 投稿时间：2018-08-07 修订日期：2018-08-30 |
| DOI：10.13241/j.cnki.pmb.2018.24.036 |
| 中文关键词: 新辅助放化疗 全直肠系膜切除术 直肠癌 疗效 |
| 英文关键词: Neoadjuvant chemoradiotherapy Total mesorectal excision Rectal cancer Curative effect |
| 基金项目:江苏省卫生和计划生育委员会科研基金项目（H2016019） |
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| 中文摘要: |
| 摘要 目的：探讨应用术前新辅助放化疗和全直肠系膜切除术（TME）治疗局部进展期直肠癌的临床疗效。方法：选择2014年1月到2016年12月我院收治的80例中低位局部进展期直肠癌患者，按照随机数字表法分为实验组（n=40）和对照组（n=40）。实验组患者给予术前新辅助放化疗联合TME治疗，对照组患者仅给予TME治疗，两组患者均于术后给予辅助化疗4个疗程。比较两组患者治疗后的病理完全缓解率、病理降期情况、根治性切除率以及不良反应发生情况。结果：实验组患者的完全缓解率为22.50%（9/40），高于对照组的5.00%（2/40），差异具有统计学意义（P<0.05）。实验组的降期率为91.89%（34/37），高于对照组的74.29%（26/35），差异具有统计学意义（P<0.05）。两组患者的根治性切除率比较差异无统计学意义（P>0.05）。治疗期间，两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：术前新辅助放化疗联合TME治疗局部进展期直肠癌安全有效，病理降期情况良好，完全缓解率较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical efficacy of preoperative neoadjuvant chemoradiotherapy combined with total mesorectal excision (TME) in the treatment of locally advanced rectal cancer. Methods: 80 patients with middle and lower locally ad- vanced rectal cancer who were treated in our hospital from January 2014 to December 2016 were selected, and they were divided into control group(n=40) and experimental group(n=40) according to the random number table method. The experiment group were treated with preoperative neoadjuvant chemoradiotherapy combined with TME, the control group were treated with TME, and the patients in two groups were given adjuvant chemotherapy for 4 courses after TME. The pathological complete remission rate, pathological descending phase condition, radical resection rate and incidence of adverse reactions between the two groups after treatment were compared. Results: The complete remission rate of the experimental group was 22.50%(9/40), which was higher than 5.00%(2/40) of the control group, the difference was statistically significant(P<0.05). The degrading rate of the experimental group was 91.89%(34/37), which was higher than 74.29%(26/35) of the control group, the difference was statistically significant(P<0.05). There was no significant difference in the radical resection rate between the two groups(P>0.05). During the treatment, there was no significant difference in the incidence of adverse reac- tions between the two groups during treatment(P>0.05). Conclusion: Preoperative neoadjuvant chemoradiotherapy combined with TME in the treatment of locally advanced rectal cancer is safe and effective, the pathological decline was good and the rate of complete remis- sion was higher. |
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