| 方恩容,何 杰,黄 娜,邱 静,代文静.经鼻高流量氧疗对阻塞性睡眠呼吸暂停综合征患者的临床疗效研究[J].,2018,(24):4723-4726 |
| 经鼻高流量氧疗对阻塞性睡眠呼吸暂停综合征患者的临床疗效研究 |
| Clinical Effect of Nasal Hyperflow Oxygen Therapy on the Patients with Obstructive Sleep Apnea Syndrome |
| 投稿时间：2018-08-07 修订日期：2018-08-31 |
| DOI：10.13241/j.cnki.pmb.2018.24.027 |
| 中文关键词: 阻塞性睡眠呼吸暂停综合征 经鼻高流量氧疗 临床疗效 |
| 英文关键词: Obstructive sleep apnea Transnasal hyperflow oxygen therapy Clinical curative effect |
| 基金项目:四川省卫生厅科研基金项目(130446) |
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| 中文摘要: |
| 摘要 目的：探讨经鼻高流量氧疗对阻塞性睡眠呼吸暂停综合征患者的临床疗效。方法：选择2013年7月至2017年7月我院接诊的80例急阻塞性睡眠呼吸暂停综合征患者进行研究，通过随机数表法分为观察组(n=45)和对照组(n=35)。观察组采用经鼻高流量氧疗进行治疗，对照组采用无创正压通气进行治疗，比较两组临床疗效、夜间呼吸暂停时间、呼吸暂停低通气指数(AHI)、总睡眠时间、醒觉时间、血氧饱和度、治疗前后血压、高敏C反应蛋白(hs-CRP)、低密度脂蛋白(LDL)、总胆固醇(TC)水平及生活质量评分的变化。结果：观察组患者治疗后有效率为88.89%，显著高于对照组(71.43%，P<0.05)。治疗后，观察组夜间最低血氧饱和度、总睡眠时间、醒觉时间、生活质量评分均明显高于对照组，AHI、收缩压、舒张压、平均动脉压、血清hs-CRP、LDL以及TC水平均显著低于对照组(P<0.05)。结论：经鼻高流量氧疗用于阻塞性睡眠呼吸暂停综合征患者的临床疗效明显优于无创正压通气进行治疗，其可显著改善患者的临床症状，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect of nasal hyperflow oxygen therapy on the patients with obstructive sleep apnea syndrome. Methods: 80 patients with acute obstructive sleep apnea syndrome were selected from July 2013 to July 2017, they were divided into the observation group(n=45) and the control group(n=35) through random indicator method. The observation group was treated with nasal high flow oxygen therapy and the control group was treated with noninvasive positive pressure ventilation, the clinical curative ef- fect, apnea at night time, apnea hypoventilation index(AHI), total sleep time, awakening time, changes of blood oxygen saturation, blood pressure, high-sensitivity c-reactive protein (hs-CRP), low density lipoprotein(LDL), total cholesterol(TC) before and after the treatment, and quality of life score were compared between tw groups. Results: After treatment, the effective rate of observation group was 88.89%, which was significantly higher than that of the control group(71.43%, P<0.05), the lowest blood oxygen saturation, total sleep time, wakefulness time and quality of life scores of observation group were significantly higher than those of the control group, and the AHI, systolic blood pressure, diastolic blood pressure, average arterial pressure, serum hs-CRP, LDL and TC levels were significantly lower than those of the control group(P<0.05). Conclusion: The clinical effect of transnasal hyperflow oxygen therapy for patients with obstruc- tive sleep apnea syndrome is obviously superior to that of non-invasive positive pressure ventilation, which can significantly improve the clinical symptoms and the quality of life. |
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