| 常桂生,沈长兵,钱 龙,秦菊芳,黄丽蓉.HALS与LAP用于直肠癌根治术患者的临床疗效及其对血清炎性因子水平的影响[J].,2018,(24):4699-4702 |
| HALS与LAP用于直肠癌根治术患者的临床疗效及其对血清炎性因子水平的影响 |
| Effect of HALS and LAP on the Efficacy and Serum Inflammatory Factors Levels in Patients Undergoing Laparoscopic Radical Resection of Rectal Cancer |
| 投稿时间：2018-08-04 修订日期：2018-08-27 |
| DOI：10.13241/j.cnki.pmb.2018.24.021 |
| 中文关键词: 手辅助腹腔镜手术 全腹腔镜手术 腹腔镜直肠癌根治术 疗效 炎性因子 |
| 英文关键词: Hand-assisted laparoscopic surgery Laparoscopic surgery Laparoscopic radical resection of rectal cancer Curative ef- fect Inflammatory factors |
| 基金项目:国家自然科学基金面上项目(81772507) |
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| 中文摘要: |
| 摘要 目的：探讨手辅助腹腔镜手术(hand-assisted laparoscopic surgery，HALS)与全腹腔镜手术(laparoscopic surgery，LAP)用于直肠癌根治术患者的临床疗效及其对血清炎性因子水平的影响。方法：选取2013年3月~2018年3月在我院行直肠癌根治术的患者61例进行回顾性分析，按照手术方式不同分为手辅助腹腔镜手术组(HALS组)和全腹腔镜手术组(LAP组)。比较两组患者的手术相关指标、术后恢复指标和治疗前后血清炎性因子水平的变化。结果：HALS组的手术时间、术中出血量和副损伤显著低于LAP组(P＜0.05)，两组中转开腹率相比无统计学差异(P＞0.05)；两组患者术后肠功能恢复时间、进食时间、下床时间和住院时间比较均无显著性差异(P＞0.05)；两组患者术后1 h和术后1 d血清白细胞介素-10(interleukin-10, IL-10)、C-反应蛋白(C reactive protein，CRP)和α肿瘤坏死因子(Tumor Necrosis Factor-α，TNF-α)水平均较术前显著升高，且HALS组显著低于LAP组(P＜0.05)，术后1 w血清IL-10、CRP和TNF-α水平与术前相比无统计学差异(P＞0.05)。结论：HALS直肠癌根治术对患者的手术创伤小，炎性反应轻，且不影响患者的预后，利于患者的康复。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of hand-assisted laparoscopic surgery (HALS) and laparoscopic surgery (LAP) on the inflammatory factors in patients undergoing laparoscopic radical resection of rectal cancer. Methods: 61 patients with rectal cancer who underwent radical resection in our hospital from March 2013 to March 2018 were retrospectively analyzed. They were divided into hand-assisted laparoscopic surgery group (HALS group) and total laparoscopic surgery group (LAP group). The operation related index, postoperative recovery index and inflammatory factor level of the two groups were compared. Results: The operation time, intraoperative bleeding volume and side injury in HALS group were significantly lower than those in LAP group(P<0.05), and there was no significant difference in the conversion rate between the two groups(P>0.05). There was no significant difference in bowel function recovery time, food intake time, out of bed time and hospitalization time between the two groups(P>0.05). The levels of interleukin-10(IL-10), C reac- tive protein(CRP) and Tumor Necrosis Factor-α(TNF-α) in HALS group were significantly higher than those in LAP group at 1 hour and 1 day after operation(P<0.05). There was no significant difference in serum IL-10, CRP and TNF-α at 1 week after operation between the two groups(P>0.05). Conclusion: HALS radical resection of rectal cancer has less trauma, mild inflammatory reaction, and does not af- fect the prognosis of patients, is conducive to the rehabilitation of patients. |
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