| 张永会,陈冬琼,彭强丽,杨丽娟,胡红娟.中西医结合保守治疗异位妊娠的十年回顾性分析研究[J].,2018,(24):4681-4685 |
| 中西医结合保守治疗异位妊娠的十年回顾性分析研究 |
| Retrospective Analysis of Conservative Treatment of Ectopic Pregnancy with Traditional Chinese and Western Medicine for Ten Years |
| 投稿时间：2018-03-23 修订日期：2018-04-18 |
| DOI：10.13241/j.cnki.pmb.2018.24.017 |
| 中文关键词: 异位妊娠 保守治疗 中西医结合治疗 疗效 不良反应 |
| 英文关键词: Etopic pregnancy Conservative treatment Combined treatment of Chinese and Western medicine Effect Adverse reaction |
| 基金项目:云南省卫生科技计划项目（2017NS141） |
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| 中文摘要: |
| 摘要 目的：回顾性分析我院十年来中西医结合保守治疗异位妊娠的病历资料，总结治疗该病的最佳用药方案。方法：回顾性分析2006年1月至2017年1月在我院接受保守治疗300例的异位妊娠患者临床资料，根据不同治疗方法分为A、B、C三组，其中A组（115例）予以50 mg/次甲氨蝶呤（MTX）+200 mg/d米非司酮+中药治疗，B组（92例）采用50 mg/次MTX+100 mg/d米非司酮+中药治疗，C组（93例）采用200 mg/d米非司酮+中药治疗。观察记录三组患者血清β-人绒毛膜促性腺激素（β-HCG）下降至正常所需时间、盆腔内包块消失时间及住院天数，记录三组患者临床疗效并统计不良反应发生情况。结果：三组间血β-HCG下降至正常时间、包块消失时间及住院天数比较差异有统计学意义（P<0.05），A组患者血β-HCG下降至正常时间、包块消失时间及住院天数均低于B组和C组，有统计学差异（P<0.05），B组和C组上述指标比较无明显差异（P>0.05）。A组、B组、C组患者治愈率分别为96.52%、85.87%、86.02%，三组患者治愈率整体比较差异有统计学意义（P<0.05），且A组患者治愈率均高于B组和C组，有统计学差异（P<0.05），B组和C组治愈率比较无明显差异（P>0.05）。A组、B组、C组的不良反应发生率分别为10.81%（12/111）、16.30%（15/92）、11.83%（11/93），三组不良反应总发生率比较无统计学差异（P>0.05）。结论：中药联合MTX和大剂量米非司酮保守治疗异位妊娠疗效高，疗程短，且安全性良好，值得推荐。 |
| 英文摘要: |
| ABSTRACT Objective: To retrospectively analyze the clinical data of ectopic pregnancy treated with traditional Chinese and West- ern medicine in our hospital during the past 10 years,and summarize the best medication plan. Methods: The clinical data of 300 cases with ectopic pregnancy treated by conservative treatment in our hospital from January 2006 to January 2017 were analyzed retrospectively, who were divided into group A, group B and group C according to the different treatment methods.Group A (115 cases) was treated with 50 mg methotrexate (MTX), 200 mg/d mifepristone and Chinese medicine treatment. Group B (92 cases) received 50mg MTX,100 mg/d mifepriston and Chinese medicine treatment. Group C(93 cases) used 200 mg/d mifepristone and Chinese medicine treatment. The de- crease time serum β-human chorionic gonadotrophin(β-HCG) to normal, the disappearance time of pelvic mass and the time of hospi- talization were observed and recorded between the three groups. The clinical efficacy and the incidence of adverse reactions between the three groups were recorded. Results: There were significant differences in the decrease time serum β-HCG to normal, the disappearance time of pelvic mass and the time of hospitalization between the three groups(P<0.05). The decrease time serum β-HCG to normal, the disappearance time of pelvic mass and the time of hospitalization in group A were lower than that in group B and group C, the differences were statistically significant(P<0.05). There was no significant difference above indicators between group B and group C(P>0.05). The cure rate in group A, group B and group C were 96.52%, 85.87%, 86.02% respectively, there were significant differences between the three groups(P<0.05). The cure rate in group A were higher than that in group B and group C, the differences were statistically signifi- cant(P<0.05). There was no significant difference of the cure rate between group B and group C(P>0.05). The incidence of adverse reac- tions in group A, group B and group C were 10.81% (12/111), 16.30% (15/92), 11.83% (11/93) respectively, there was no significant dif- ference of the total incidence of adverse reactions between the three groups(P>0.05). Conclusion: Chinese medicine treatment combined with MTX and large dose of mifepristone in the conservative treatment of ectopic pregnancy has high curative effect, short course and good safety, it is worth recommending. |
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