| 甘 芳,阿小英,刘 哲,鲍统惠,张 欣.子宫内膜异位症患者血清中TNF-α、LXA4、YKL-40的表达及其与r-AFS分期和痛经程度的关系[J].,2018,(23):4518-4521 |
| 子宫内膜异位症患者血清中TNF-α、LXA4、YKL-40的表达及其与r-AFS分期和痛经程度的关系 |
| Expression of TNF-α, LXA4 and YKL-40 in Serum of Patients with Endometriosis and Its Relationship with r-AFS Stage and Dysmenorrhea |
| 投稿时间：2018-05-25 修订日期：2018-06-20 |
| DOI：10.13241/j.cnki.pmb.2018.23.028 |
| 中文关键词: 子宫内膜异位症 肿瘤坏死因子-α 免疫脂氧素A4 甲壳质酶蛋白40 r-AFS分期 痛经程度 相关性 |
| 英文关键词: Endometriosis Tumor necrosis factor-α Immune lipoxin A4 Chitinase protein 40 r-AFS stage Dysmenorrhea Corre- lation |
| 基金项目:青海省科技厅基金资助项目（2013JJ0153） |
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| 中文摘要: |
| 摘要 目的：探讨子宫内膜异位症（EMs）患者血清中肿瘤坏死因子-α（TNF-α）、免疫脂氧素A4（LXA4）、甲壳质酶蛋白40（YKL-40）的表达及其与美国生育协会（r-AFS）分期和痛经程度的关系。方法：选取我院于2017年1月~2018年1月期间收治的EMs患者92例作为研究组。根据r-AFS分期将患者分为I期20例，II期28例，III期26例，IV期18例。根据不同痛经程度将患者分为无疼痛14例，轻度24例，中度32例，重度22例。另选取同期因卵巢良性囊肿、子宫腺肌瘤等行腹腔镜术治疗的患者30例为对照组。检测并比较两组血清TNF-α、LXA4、YKL-40水平；比较不同r-AFS分期和不同痛经程度患者血清TNF-α、LXA4、YKL-40水平；采用Pearson相关性分析方法分析血清TNF-α、LXA4、YKL-40水平与r-AFS分期和痛经程度的相关性。结果：研究组患者TNF-α、YKL-40水平均显著高于对照组，而LXA4水平显著低于对照组（P<0.05）。随着r-AFS分期的升高，EMs患者血清TNF-α、YKL-40水平逐渐升高，LXA4水平逐渐降低（P<0.05）。随着痛经程度的增加，EMs患者血清TNF-α、YKL-40水平逐渐升高，LXA4水平逐渐降低（P<0.05）。Pearson相关性分析显示，EMs患者TNF-α、YKL-40水平与r-AFS分期和痛经程度呈正相关，LXA4与r-AFS分期和痛经程度呈负相关（P<0.05）。结论：EMs患者中血清TNF-α、YKL-40水平呈高表达，LXA4呈低表达。上述指标与EMs患者r-AFS分期和痛经程度关系密切，可考虑将其作为临床诊断EMs的生物学指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of tumor necrosis factor -α (TNF-α),immuno - lipoxygenin A4 (LXA4) and chitinase protein 40 (YKL-40) in patients with endometriosis (EMs) and its relationship to the stage of American Fertility Association (r-AFS) and the degree of dysmenorrhea. Methods: 92 patients with EMs who were admitted to our hospital from January 2017 to Jan- uary 2018 were selected as the study group. According to r-AFS, the patients were divided into I stage with 20 cases, II stage with 28 cases, III stage with 26 cases, IV stage with 18 cases. According to the degree of dysmenorrhea,the patients were divided into no pain with 14 cases, light with 24 cases, moderate with 32 cases and severe with 22 cases. Another 30 patients who underwent laparoscopic surgery for uterine adenomyoma and ovarian benign cyst were selected as control group. The serum levels of TNF-α, LXA4 and YKL-40 were de- tected and compared between the two groups. The serum levels of TNF-α, LXA4 and YKL-40 in patients with different r-AFS staging and different dysmenorrhea were compared. The correlation between serum TNF-α, LXA4, YKL-40 level and r-AFS staging and dys- menorrhea score was analyzed by Pearson correlation analysis. Results: The levels of TNF-α and YKL-40 in the study group were sig- nificantly higher than those in the control group, while the LXA4 level was significantly lower in the study group than that in the control group(P<0.05). With the increase of r-AFS stage, serum TNF-α and YKL-40 levels in EMs patients gradually increased, and LXA4 levels gradually decreased(P<0.05). With the increase of the scores of different dysmenorrhea, the levels of TNF-α and YKL-40 in EMs pa- tients gradually increased, while LXA4 levels gradually decreased(P<0.05). TNF-α and YKL-40 levels in EMs patients were positively correlated with r-AFS stage and dysmenorrhea score. LXA4 was negatively correlated with r-AFS stage and dysmenorrhea score. Conclusion: The serum levels of TNF-α and YKL-40 were highly expressed in EMs patients and LXA4 was low. These indicators are closely re- lated to the r-AFS stage and dysmenorrhea in EMs patients, and they can be considered as biological indicators for clinical diagnosis of EMs. |
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