| 胡 浩,马向华,高云明,姜海燕,彭玲玲,周 萍.糖尿病肾病患者血清亲环素水平及其临床意义[J].,2018,(23):4470-4473 |
| 糖尿病肾病患者血清亲环素水平及其临床意义 |
| Serum Levels of Cyclophilin A in Patients with Diabetes Nephropathy and Its Clinical Significance |
| 投稿时间：2018-03-29 修订日期：2018-04-25 |
| DOI：10.13241/j.cnki.pmb.2018.23.016 |
| 中文关键词: 糖尿病肾病 血清亲环素A 尿蛋白排泄率 肾损伤 雷公藤多甙片 |
| 英文关键词: Diabetic nephropathy Serum cyclophilin A Urinary albumin excretion rate Kidney injury Tripterygium glycosides |
| 基金项目:连云港市卫生计生委科技项目(201613)；江苏省中医药管理局科技项目(YB2015164） |
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| 中文摘要: |
| 摘要 目的：探讨糖尿病肾病(DN)患者血清亲环素A(CyPA)水平及其临床意义。方法：将我院2014年10月-2015年10月收治的86例2型糖尿病肾病(T2DN)患者依据24 h尿白蛋白排泄率(UAER)水平分为3组，即糖尿病无肾病组(SDM组) 30例、早期糖尿病肾病组(EDN组)28例、糖尿病肾病组(CDN组)28例。另选取同期本院健康体检者26例为对照组(NC组)。比较4组的血清CyPA水平、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbA1c)、血肌酐(Cr)、尿素氮(BUN)水平。以EDN组为实验组，在常规控制血压、血糖、血脂等基础上，给予小剂量雷公藤多甙片治疗4周，分析CyPA水平与24 h UAER的相关性。结果：SDM组、EDN组、CDN组的HbAlc水平显著高于CN组(P<0.05)。EDN组、CDN组的24 h UAER水平显著高于SDM组和CN组(P<0.05)，CDN组的24 h UAER水平显著高于EDN组(P<0.05)，而EDN组和CN组的24 h UAER水平比较差异无统计学意义(P>0.05)。SDM组、EDN组、CDN组、CN组血清CyPA水平依次升高，两两比较差异均有统计学意义(P<0.05)。糖尿病肾病患者血清CyPA水平与24 h UAER呈正相关(r=0.697，P<0.05)。结论：血清CyPA水平在一定程度上能反映糖尿病肾病患者的肾损伤严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the level of serum cyclophilin A (CyPA) in diabetic nephropathy (DN) and its clinical signifi- cance. Methods: 86 cases of type 2 diabetic nephropathy (T2DN) in our hospital from October 2014 to October 2015 were divided into three groups according to the results of 24 h urinary albumin excretion rate(UAER), namely diabetes nephropathy group(SDM group) 30 cases and the early diabetic nephropathy group(EDN group) 28 cases, diabetic nephropathy group(CDN group) 28 cases. The other se- lected healthy physical examination in our hospital, 26 patients of control group (NC group) and compared between the 4 groups. The level of serum CyPA, systolic blood pressure(SBP), diastolic bloodpressure(DBP), Glycosylated hemoglobin(HbA1c), serum creatinine(Cr), blood urea nitrogen(BUN) level in the EDN group, in the conventional control of blood pressure, blood glucose, blood lipid on the basis of giving small doses of Tripterygium wilfordii tablets for 4 weeks. The analysis of correlation between CyPA level and 24 h UAER. Results: SDM group, EDN group, CDN group, HbAlc level was significantly higher than that of group CN(P<0.05). EDN group, CDN group of 24 h UAER was significantly higher than that of SDM group and CN group(P<0.05), CDN group of 24 h UAER was sig- nificantly higher than that of EDN group(P<0.05), while no significant group EDN and CN a group of 24 h UAER level difference(P>0.05) in. SDM group, EDN group, CDN group, CyPA group, the level of serum CN increased 22, there were significant differences(P<0.05). The serum CyPA level in patients with diabetic nephropathy was positively correlated with 24 h UAER(r=0.697, P<0.05). Conclusion: serum CyPA level can reflect the severity of renal injury in diabetic nephropathy patients. |
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