| 梁 楠,翁巧风,赵 翀,宁立强,李志艳.龈沟液中骨硬化蛋白对慢性牙周炎患者疗效评价的临床价值[J].,2018,(22):4366-4369 |
| 龈沟液中骨硬化蛋白对慢性牙周炎患者疗效评价的临床价值 |
| Clinical Value of Osteoclast Protein in Gingival Crevicular Fluid for the Clinical Efficacy Evaluation of Patients with Chronic Periodontitis |
| 投稿时间：2018-07-06 修订日期：2018-07-30 |
| DOI：10.13241/j.cnki.pmb.2018.22.038 |
| 中文关键词: 龈沟液 骨硬化蛋白 慢性牙周炎 诊断 疗效评价 |
| 英文关键词: Gingival crevicular fluid Osteopetrosis protein Chronic periodontitis Diagnosis Efficacy evaluation |
| 基金项目:青海省科技计划基金资助项目(2017-ZJ-736) |
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| 中文摘要: |
| 摘要 目的：探讨龈沟液中骨硬化蛋白对慢性牙周炎疗效评价的临床价值。方法：选择2013年1月-2017年12月我院收治的81例慢性牙周炎患者作为观察组及同期79例牙周健康者为对照组，观察组患者给予基础治疗。观察和比较对照组和观察组治疗前及治疗后1个月、2个月的牙周临床指标、龈沟液中的骨硬化蛋白水平，并分析牙周临床指标与龈沟液骨硬化蛋白水平的相关性。结果：治疗前，观察组的菌斑指数、出血指数、牙周探诊深度、附着丧失水平及龈沟液中骨硬化蛋白水平明显高于对照组；治疗后1个月、2个月，观察组以上指标均明显低于治疗前，且治疗后2个月，观察组以上指标明显低于治疗后1个月，但附着丧失水平仍高于对照组 (P均<0.05)，而两组的菌斑指数、出血指数、牙周探诊深度对比差异无统计学意义(P>0.05)。龈沟液中骨硬化蛋白水平与菌斑指数、出血指数、牙周探诊深度、附着丧失水平呈高度正相关(r1=0.876，P1<0.001；r2=0.842，P1<0.00；r3=0.913，P1<0.001；r4=0.903，P1<0.001)。结论：慢性牙周炎患者龈沟液中骨硬化蛋白水平明显上调，并与与菌斑指数、出血指数、牙周探诊深度、附着丧失水平呈高度正相关，可作为慢性牙周炎疗效评价的参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical value of sclerosing protein in gingival crevicular fluid for the curative effect evaluation of chronic periodontitis. Methods: 81 patients with chronic periodontitis treated in our hospital from January 2013 to December 2017 were selected as the observation group, and 79 cases of periodontal health in the same period were selected as the control group. Patients in the observation group were treated by basic treatment. The clinical index of periodontal disease and the level of osteosclerin in gingival crevicular fluid before and after treatment were compared between two groups, and the correlation of periodontal clinical index with the level of sclerosing protein in gingival crevicular fluid was also analyzed. Results: Before treatment, the plaque index, bleeding index, depth of periodontal detection, loss of attachment and level of bone sclerosis protein in the gingival crevicular fluid of observation group were significantly higher than those in the control group. After 1 month and 2 months of treatment, the above index were significantly lower than those before treatment; and after 2 months of treatment, the index above in the observation group were significantly lower than those after 1 month of treatment. But the loss of attachment was still higher than that of the control group (P <0.05), there was no significant difference in the plaque index, bleeding index, and depth of periodontal detection between the two groups(P>0.05). The level of sclerosing protein in gingival crevicular fluid was highly correlated with plaque index, bleeding index, periodontal detection depth and loss of attachment (r1=0.876, P1<0.001; r2=0.842, P1<0.00; r3=0.913, P1<0.001; r4=0.903, P1<0.001). Conclusion: The level of osteosclerin in gingival crevicular fluid is significantly up-regulated in patients with chronic periodontitis, it is highly correlated with plaque index, bleeding index, periodontal probing depth, and loss of attachment and can be used as reference indicators for the clinical efficacy evaluation. |
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