| 关信民,邹月柳,吕嘉春,赵 强,杨尚珂.藏族原发性高血压患者血管内皮功能与糖脂代谢指标和血压变异性的关系[J].,2018,(22):4261-4264 |
| 藏族原发性高血压患者血管内皮功能与糖脂代谢指标和血压变异性的关系 |
| Relationship between Vascular Endothelial Function and Glycolipid Metabolism Indexes and Blood Pressure Variability in Tibetan Patients with Essential Hypertension |
| 投稿时间：2018-06-15 修订日期：2018-07-09 |
| DOI：10.13241/j.cnki.pmb.2018.22.013 |
| 中文关键词: 原发性高血压 藏族 糖脂代谢 血压变异性 血管内皮功能 |
| 英文关键词: Essential hypertension Tibetan Glycolipid metabolism Blood pressure variability Vascular endothelial function |
| 基金项目:广东省科技计划基金资助项目（2013B021800033） |
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| 中文摘要: |
| 摘要 目的：研究藏族原发性高血压患者血管内皮功能与糖脂代谢指标和血压变异性的关系。方法：以2017年2月-2018年2月暨南大学医学院附属广州红十字会医院收治的200例藏族原发性高血压患者为研究对象。将所有患者按照肱动脉血流介导的血管舒张功能（FMD）值分为正常FMD组（FMD≥6%）48例与异常FMD组（FMD<6%）152例。分别比较两组患者的基本资料、糖脂代谢指标以及血压变异性指标水平，并分析藏族原发性高血压患者FMD与糖脂代谢和血压变异性的相关性。结果：异常FMD组年龄、空腹血糖水平高于正常FMD组（P<0.05），而两组总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平对比差异均无统计学意义（P>0.05）。异常FMD组日间收缩压、日间舒张压、夜间收缩压、夜间舒张压、24h收缩压、24h舒张压水平均高于正常FMD组（P<0.05）。经Preason相关性分析可得：藏族原发性高血压患者FMD值与空腹血糖、日间收缩压、日间舒张压、夜间收缩压、夜间舒张压、24h收缩压、24h舒张压均呈负相关关系（P<0.05）。结论：藏族原发性高血压患者血管内皮功能受损越严重，其空腹血糖、血压就越高，临床工作中可通过联合检查上述指标水平，有助于评估藏族原发性高血压患者血管内皮功能。 |
| 英文摘要: |
| ABSTRACT Objective: To study the relationship between vascular endothelial function and glycolipid metabolism indexes and blood pressure variability in Tibetan patients with essential hypertension. Methods: A total of 200 Tibetan patients with essential hypertension, who were treated in Guangzhou Red Cross Hospital Affiliated to Jinan University School of medicine from February 2017 to February 2018, were selected as research subjects. All the patients were divided into normal FMD group (FMD≥6%)(n=48) and abnormal FMD group (FMD<6%)(n=152) according to the blood flow mediated vascular diastolic function (FMD) value of brachial artery. The basic data, the levels of glycolipid metabolism indexes and blood pressure variability indexes of the two groups were compared. The correlation between FMD and glycolipid metabolism and blood pressure variability in Tibetan patients with essential hypertension were analyzed. Results: Age and the level of fasting blood glucose in the abnormal FMD group were higher than those in the normal FMD group (P<0.05). There were no significant differences in total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) between the two groups (P>0.05). The levels of daytime systolic pressure, daytime diastolic pressure, night systolic pressure, night diastolic pressure, 24h systolic pressure and 24h diastolic pressure in the abnormal FMD group were all higher than those in the normal FMD group (P<0.05). The results of Preason correlation analysis showed that the FMD values of Tibetan patients with essential hypertension were negatively correlated with fasting blood glucose, daytime systolic pressure, daytime diastolic pressure, night systolic pressure, night diastolic pressure, 24h systolic pressure and 24h diastolic pressure (P<0.05). Conclusion: The more serious damage of vascular endothelial function is in Tibetan patients with essential hypertension, the more higher levels of fasting blood glucose and blood pressure are.In clinical work,joint examination of these indicators can help assess endothelial function in Tibetan patients with essential hypertension. |
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