| 赖玉姝,赵衍江,刘甲辰,王连喜,李素娥.CK-MB、hs-CRP和cTnI联合检测病毒性心肌炎患儿的临床价值研究[J].,2018,(20):3937-3940 |
| CK-MB、hs-CRP和cTnI联合检测病毒性心肌炎患儿的临床价值研究 |
| Clinical Value Study of Combined Detection of CK-MB, hs-CRP and cTnI in Children with Viral Myocarditis |
| 投稿时间：2018-03-21 修订日期：2018-04-17 |
| DOI：10.13241/j.cnki.pmb.2018.20.031 |
| 中文关键词: 病毒性心肌炎 心肌肌钙蛋白Ｉ 肌酸激酶同工酶 超敏Ｃ反应蛋白 临床价值 |
| 英文关键词: Viral myocarditis Cardiac troponin I Creatine kinase-MB Hypersensitivity C reactive protein Clinical value |
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| 中文摘要: |
| 摘要 目的：探讨肌酸激酶同工酶（CK-MB）、超敏C反应蛋白（hs-CRP）和心肌肌钙蛋白I（cTnI）联合检测病毒性心肌炎（VMC）患儿的临床价值。方法：选取2015年7月-2017年3月在本院确诊的70例VMC患儿为观察组，选取同期在本院体检的70例健康儿童为对照组，在入院后第2d、第3d、第5d、第7d、第9d和第11d分别测定所有儿童血清CK-MB、cTnI和hs-CRP水平，分析比较三项指标联合检测和单独检测的灵敏度、特异性和准确性。结果：观察组患儿血清 CK-MB、cTnI、hs-CRP水平均高于对照组，差异有统计学意义（P<0.05）。观察组患儿CK-MB、cTnI和hs-CRP联合检测的灵敏度和准确性分别为90.12%、93.62%，均高于单独检测，差异有统计学意义（P<0.05），三项指标联合检测的特异性高于hs-CRP单独检测，差异有统计学意义（P<0.05）。检测结果显示，hs-CRP阳性率最高，但在血清中也最先消失，CK-MB次之，cTnI最慢。差异有统计学意义（P<0.05）。结论：采用CK-MB、cTnI和hs-CRP的联合检测，可提高检测VMC患儿的灵敏度和准确性，更具有临床诊断价值。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical value of combined detection of creatine kinase-MB (CK-MB), hypersensitivity C reactive protein (hs-CRP) and cardiac troponin I (cTnI) in children with viral myocarditis (VMC). Methods: 70 children diagnosed with VMC in our hospital from July 2015 to March 2017 were selected as the observation group, and 70 healthy children in the same period were selected as the control group. The serum levels of CK-MB, cTnI and hs-CRP were measured in the 2d, 3d, 5d, 7d, 9d, 11d after admission. The sensitivity, specificity and accuracy of combined detection and single detection of three indicators were analyzed and compared. Results: The serum levels of CK-MB, cTnI and hs-CRP in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05). The sensitivity and accuracy of the combined detection of CK-MB, cTnI and hs-CRP in the observation group were 90.12% and 93.62% respectively,which were higher than those of the single detection, the differences were statistically significant (P<0.05). The specificity of combined detection of three indicators was higher than that of hs-CRP single detection, the differences were statistically significant (P<0.05). The detection results showed that the positive rate of hs-CRP was the highest, but it disappeared first in the serum, followed by CK-MB, and cTnI was the slowest. The levels of CK-MB, cTnI and hs-CRP and the positive rate of the observation group showed downward trend, the differences were statistically significant (P<0.05). Conclusion: The combined detection of CK-MB, cTnI and hs-CRP can improve the sensitivity and accuracy of detection of VMC,and it has clinical diagnostic value. |
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