| 田 心,刘超峰,谢华宁,李 蕊,李 玲.前列地尔联合硝酸异山梨酯对不稳定性心绞痛患者血清细胞因子及血液流变学的影响[J].,2018,(20):3905-3908 |
| 前列地尔联合硝酸异山梨酯对不稳定性心绞痛患者血清细胞因子及血液流变学的影响 |
| Effects of Alprostadil and Isosorbide Dinitrate on Serum Cytokines and Hemorheology in Patients with Unstable Angina Pectoris |
| 投稿时间：2018-03-27 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2018.20.023 |
| 中文关键词: 不稳定性心绞痛 前列地尔 硝酸异山梨酯 细胞因子 血液流变学 |
| 英文关键词: Unstable angina pectoris Alprostadil Isosorbide dinitrate Cytokines Hemorheology |
| 基金项目:陕西省科技统筹创新工程计划项目（2016KTZDSF01-03-02）；陕西省中医药管理局科研项目（2017JCMS009） |
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| 中文摘要: |
| 摘要 目的：探讨前列地尔联合硝酸异山梨酯对不稳定性心绞痛（UAP）患者血清细胞因子及血液流变学的影响。方法：选取2015年3月-2016年12月期间我院收治的UAP患者86例为研究对象，按照治疗方式的不同分为对照组和实验组，每组各43例。对照组给予硝酸异山梨酯治疗，实验组在硝酸异山梨酯的基础上加用前列地尔治疗，两组均连续治疗14d。对比两组治疗前后血清细胞因子水平变化、血液流变学参数变化、临床疗效以及不良反应发生情况。结果：治疗后两组白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）水平均明显降低，白细胞介素-10（IL-10）水平明显升高（P<0.05），且实验组IL-6、TNF-α、hs-CRP水平较对照组降低，IL-10水平较对照组升高（P<0.05）。治疗后两组舒张功能指数（O/C）、总电机械收缩期（QA2）、总外周阻力（TPR）均降低，每搏做功（SW）、搏功指数（SWI）、心脏指数（CI）、主动脉血管顺应性（AC）均升高（P<0.05），治疗后实验组O/C、QA2、TPR较对照组降低，SW、SWI、CI、AC较对照组升高（P<0.05）。实验组总有效率为95.35%，高于对照组的81.40%（P<0.05）。两组治疗期间不良反应发生率比较差异无统计学意义（P>0.05）。结论：前列地尔联合硝酸异山梨酯治疗UAP患者具有较好的疗效，可以控制患者的炎症反应，改善患者的血液流变学，无严重不良反应发生，值得临床推广。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of alprostadil and isosorbide dinitrate on serum cytokines and hemorheology in patients with unstable angina pectoris (UAP). Methods: 86 patients with UAP who were treated in our hospital from March 2015 to December 2016 were selected as the research subjects. According to the different methods of treatment, the patients were divided into the control group and the experimental group, 43 cases in each group. The control group was treated with isosorbide dinitrate alone, and the experimental group was treated with alprostadil on the basis of isosorbide dinitrate. The two groups were treated continuously for 14 days. The changes of serum cytokine level before and after treatment, hemorheological parameters, clinical effect and adverse reaction were compared in the two groups. Results: After treatment,interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), hypersensitive C reactive protein (hs-CRP) of the two groups were significantly decreased,and the interleukin-10 (IL-10) was significantly increased (P<0.05), after treatment, the levels of IL-6, TNF-α, and hs-CRP in the experimental group were lower than those in the control group, and the level of IL-10 was higher than that in the control group (P<0.05). After treatment, the diastolic function index (O/C), total electromechanical systole (QA2) and total peripheral resistance (TPR) of the two groups were all decreased, and stroke work (SW), stroke work index (SWI), cardiac index (CI) and aortic vascular compliance (AC) were increased (P<0.05). After treatment, the O/C, QA2 and TPR in the experimental group were lower than those in the control group, and the SW, SWI, CI and AC were higher than those of the control group (P<0.05). The total effective rate of the experimental group was 95.35%, which was higher than that of the control group (81.40%)(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the treatment (P>0.05). Conclusion: Alprostadil combined with isosorbide dinitrate have a good efficacy in the treatment of patients with UAP. It can control the patient's inflammatory reaction, improve the hemorheology of the patient, and no serious adverse reactions occur, which is worthy of clinical promotion. |
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