| 张越虹,马义丽,慈丽娟,徐 毅,桑 莉.血清γ-谷氨酰转移酶与冠心病影响因素及血管病变严重程度的相关性研究[J].,2018,(19):3716-3719 |
| 血清γ-谷氨酰转移酶与冠心病影响因素及血管病变严重程度的相关性研究 |
| Correlation of Serum γ-Glutamyltransferase Level with the Risk Factors and the Severity of Coronary artery Lesion of Patients with Coronary Heart Disease |
| 投稿时间：2018-03-04 修订日期：2018-03-28 |
| DOI：10.13241/j.cnki.pmb.2018.19.026 |
| 中文关键词: γ-谷氨酰转移酶 冠心病 影响因素 血管病变 |
| 英文关键词: GGT Coronary heart disease Influencing factors Degree of vascular lesions |
| 基金项目:辽宁省自然科学基金指导计划项目（201602220） |
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| 中文摘要: |
| 摘要 目的：探究血清γ-谷氨酰转移酶(GGT)水平与冠心病影响因素及患者血管病变严重程度之间的相关性。方法：选取2013年7月至2017年10月于我院经冠状动脉造影确诊为冠心病的61例患者为实验组，将其按照临床症状分为稳定性心绞痛组(下简称A组，20例)、不稳定性心绞痛组(下简称B组，21例)和急性心肌梗死组(下简称C组，20例)，另选取同期于我院进行冠脉造影检查确诊为非冠心病的30例患者为对照组，检测和比较四组患者的空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、收缩压(SBP)、舒张压(DBP)、尿酸等水平，而分析GGT与危险因素、冠脉Gensini评分的相关性。结果：(1)实验组患者血清FBG、TC、TG、SBP、DBP、尿酸水平均高于对照组患者，差异具有统计学意义(P<0.05)；(2)GGT水平与冠心病上述危险因素呈正相关性（r=0.236、0.351、0.316、0.239、0.301、0.395，P=0.035、0.000、0.000、0.034、0.001、0.000）；(3)四组患者GGT及Gensini评分均按照C组>B组>A组>对照组的趋势变化，且各组间对比差异具有统计学意义(P<0.05)；(4)冠心病患者血清GGT水平与Gensini评分呈正相关性(r=0.681，P=0.000)。结论：冠心病患者血清GGT水平与血清FBG、TC、TG、SBP、DBP、尿酸水平及血管病变的严重程度均呈显著正相关，其可能作为预测冠心病患者病变程度的参考指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of serum γ-glutamyl transferase (GGT) level with the influencing factors of coronary heart disease and the severity of patients with vascular disease. Methods: 61 patients diagnosed as coronary heart disease(CHD) from July 2013 to October 2017 in our hospital through coronary angiography were selected as the experimental group, which were di- vided into stable angina pectoris group (hereinafter referred to as A group, 20 cases), unstable angina (group B, 21 cases) and acute myo- cardial infarction (group C, 20 cases) according to their clinical symptoms. In the same period, thirty patients without coronary heart dis- ease were selected as the control group. The levels of fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and uric acid in the four groups were measured and compared. The correlation of coronary Gensini score. Finally, the GGT and Gensini scores of four groups of patients were analyzed. Results: (1) The FBG, serum TC, TG, SBP, DBP and uric acid levels in the four groups were significantly different(Group C>Group B>Group A>Control group, P<0.05); (2)The level of GGT was positively correlated with the above risk factors(r=0.236, 0.351, 0.316, 0.239, 0.301, 0.395, P=0.035, 0.000, 0.000, 0.0034, 0.001, 0.000); (3)Both GGT and Gensini scores in the four groups were changed according to the trend of Group C>Group B>Group A>Control group(P<0.05); (4) The serum GGT level of patients with coronary heart disease was positively correlated with Gensini score(r=0.681, P=0.000). Conclusion: The serum GGT levels of CHD patients were positively correlated with the serum levels of FBG, TC, TG, SBP, DBP, uric acid levels and the severity of the vascular lesions, it may be used to predict the severity of lesion in CHD patients. |
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