| 钟 兰,刘梦琼,吴 华,刘玲丽,符 宁.胃癌患者血清CA125、CA724、CEA、CA199水平的表达及与临床病理特征的关系研究[J].,2018,(18):3550-3553 |
| 胃癌患者血清CA125、CA724、CEA、CA199水平的表达及与临床病理特征的关系研究 |
| Expression of Serum CA125, CA724, CEA, CA199 Levels in Patients with Gastric Cancer and Its Relationship with Clinicopathological Features |
| 投稿时间：2018-02-05 修订日期：2018-02-28 |
| DOI：10.13241/j.cnki.pmb.2018.18.034 |
| 中文关键词: 胃癌 糖链抗原125 糖链抗原724 癌胚抗原 糖链抗原199 病理特征 |
| 英文关键词: Gastric cancer Sugar chain antigen 125 Sugar chain antigen 724 Carcinoembryonic antigen Sugar chain antigen 199 Pathological features |
| 基金项目:海南省医学科研立项课题（琼卫2012 PT-17） |
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| 中文摘要: |
| 摘要 目的：研究胃癌患者血清糖链抗原125（CA125）、糖链抗原724（CA724）、癌胚抗原（CEA）、糖链抗原199（CA199）水平的表达及与临床病理特征的关系。方法：选取2016年5月-2017年8月我院收治的胃癌患者94例记为胃癌组，胃部良性病变患者82例记为良性病变组，另取同期于我院接受体检的健康志愿者80例记为对照组。分别测定三组受试者血清CA125、CA724、CEA、CA199水平，并分析上述指标与胃癌患者临床病理特征的关系，并观察胃癌患者各指标单独检测和联合检测的阳性率。结果：三组受试者血清CA125、CA724、CEA、CA199水平整体比较差异有统计学意义（P<0.05），胃癌组、良性病变组、对照组的血清CA125、CA724、CEA、CA199水平呈逐渐降低趋势，两两对比差异有统计学意义（P<0.05）。不同性别的胃癌患者CA125、CA724、CEA、CA199水平比较差异无统计学意义（P>0.05），年龄>60岁、TNM分期为Ⅲ-Ⅳ期、肿瘤大小≥5 cm2的胃癌患者CA125、CA724、CEA、CA199水平均高于年龄≤60岁、TNM分期为Ⅰ-Ⅱ期、肿瘤大小<5 cm2的胃癌患者，差异有统计学意义（P<0.05）。联合检测的胃癌阳性率高于CA125、CA724、CEA、CA199单独检测，且CA724单独检测高于CA125、CEA、CA199单独检测，差异有统计学意义（P<0.05）。结论：胃癌患者血清CA125、CA724、CEA、CA199水平较高，与患者的年龄、TNM分期、肿瘤大小等因素有关，且联合检测的胃癌检出率较高，可为胃癌的早期诊断提供指导作用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of serum carbohydrate antigen 125 (CA125), carbohydrate antigen 724 (CA724), carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA199) levels in patients with gastric cancer and its relation- ship with clinicopathological features. Methods: 94 patients with gastric cancer who were treated in our hospital from May 2016 to Au- gust 2017 were selected as gastric cancer group, and 82 patients with benign gastric lesions were selected as benign lesions group. In ad- dition, 80 healthy volunteers who were received medical examination in our hospital at the same time were selected as the control group. The levels of serum CA125, CA724, CEA and CA199 of subjects in three groups were measured, and the relationship between the above indexes and the clinicopathological features of gastric cancer were analyzed. The positive rate of alone and combined detection of each indexes in patients with gastric cancer was observed. Results: There was statistically significant difference in overall comparison of serum CA125, CA724, CEA and CA199 in the three groups(P<0.05). The levels of serum CA125, CA724, CEA and CA199 in gastric cancer group, benign lesion group and control group were decreased gradually, and the difference between each groups was statistically signifi- cant (P<0.05). There was no significant difference in the levels of CA125, CA724, CEA and CA199 in patients with gastric cancer with different sex (P>0.05). The levels of serum CA125, CA724, CEA and CA199 in patients with gastric cancer with age >60 years old, TNM stage III - IV stage, tumor size ≥5 cm2 were higher than that of age ≤60 years old, TNM stage I-II stage and tumor size <5 cm2, the difference was statistically significant (P<0.05). The positive rate of combined detection of gastric cancer was higher than that of CA125, CA724, CEA and CA199 alone, and the positive rate of CA724 alone was higher than that of CA125, CEA and CA199 alone, the difference was statistically significant (P<0.05). Conclusion: The levels of serum CA125, CA724, CEA and CA199 are higher in pa- tients with gastric cancer, which are related to the age, TNM stage and tumor size. The combined detection rate of gastric cancer is higher, which can provide guidance for early diagnosis of gastric cancer. |
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