| 李 婷,朱建福,毛瑛玉,林茂华,林妙春,沈丽蕊.半乳糖凝集素-3与程序性死亡受体-1在宫颈鳞癌组织中的表达及其临床意义[J].,2018,(18):3529-3532 |
| 半乳糖凝集素-3与程序性死亡受体-1在宫颈鳞癌组织中的表达及其临床意义 |
| Expression and Clinical Significance of Galectin -3 and Programmed Death Receptor -1 in Cervical Squamous Cell Carcinoma |
| 投稿时间：2018-03-16 修订日期：2018-04-22 |
| DOI：10.13241/j.cnki.pmb.2018.18.029 |
| 中文关键词: 宫颈鳞癌 半乳糖凝集素-3 程序性死亡受体-1 表达 临床意义 |
| 英文关键词: Cervical squamous cell carcinoma Galectin-3 Programmed death receptor -1 Expression significance Clinicopatho- logical features |
| 基金项目:福建省自然科学基金项目（2015J01572）；福建省青年科研基金项目（2013-1-48） |
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| 中文摘要: |
| 摘要 目的：探讨半乳糖凝集素-3（Gal-3）和程序性死亡受体-1（PD-1）在宫颈鳞癌组织中的表达及其临床意义。方法：选择2016年1月-2017年12月期间我院收治的宫颈鳞癌患者80例纳入观察组，宫颈上皮内瘤变（CIN）患者60例纳入CIN组，取同期在我院进行治疗的宫颈炎患者50例纳入对照组。采集三组患者的宫颈组织标本，采用免疫组化SP法对各组织标本中的Gal-3、PD-1的阳性率、表达水平进行检测，并分析Gal-3、PD-1与宫颈鳞癌临床病理特征的关系以及各指标表达水平的相关性。结果：观察组、CIN组的Gal-3、PD-1的阳性表达率、表达水平均高于对照组，且观察组高于CIN组（P<0.05）。Gal-3、PD-1的表达与宫颈鳞癌患者的年龄、病灶大小、分化程度无关（P>0.05），而与宫颈鳞癌肿瘤的分期、淋巴结转移有关（P<0.05）。经Spearman相关性分析显示，宫颈鳞癌组织中Gal-3与PD-1间表达水平呈正相关性（r=0.496，P=0.000）。结论：Gal-3、PD-1的表达水平与宫颈鳞癌的发生、发展有密切关联，并且两种指标间呈明显正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression and clinical significance of galectin-3 (Gal-3) and programmed death receptor -1 (PD-1) in squamous cell carcinoma of the cervix. Methods: 80 patients with cervical squamous cell carcinoma who were admitted to our hospital from January 2016 to December 2017 were included in the observation group, 60 patients with cervical intraepithelial neo- plasia (CIN) were included in the CIN group. 50 patients with cervicitis who were treated in our hospital during the same period were in- cluded in the control group. The cervical tissue specimens from three groups were collected, the positive rate and expression level of Gal-3 and PD-1 in tissue samples were detected by immunohistochemical SP method, the relationship between Gal-3 and PD-1 and the clinicopathological characteristics of cervical squamous cell carcinoma and the correlation between the expression levels of various indi- cators were analyzed. Results: The positive expression rate and expression level of Gal-3 and PD-1 in the observation group and CIN group were all higher than those in the control group, and the observation group was higher than that in the CIN group (P<0.05). The ex- pression of Gal-3 and PD-1 were not related to the age, size and degree of differentiation of cervical squamous cell carcinoma (P>0.05), it was related to the stage and lymph node metastasis of cervical squamous cell carcinoma (P<0.05). Spearman correlation analysis showed that the expression level of Gal-3 and PD-1 was positively correlated in cervical squamous cell carcinoma (r=0.496, P=0.000). Conclusion: The expression level of Gal-3 and PD-1 is closely related to the occurrence and development of cervical squamous cell carcinoma, and there is a significant positive correlation between the two indicators. |
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