| 殷 董,孙晓燕,王星武,杨 帆,崔 莉.特异性免疫疗法治疗慢性荨麻疹患者的疗效及对血清IgE、IL-4、IFN-γ和生活质量的影响[J].,2018,(18):3494-3497 |
| 特异性免疫疗法治疗慢性荨麻疹患者的疗效及对血清IgE、IL-4、IFN-γ和生活质量的影响 |
| Curative Effect of Specific Immunotherapy on Patients with Chronic Urticaria and its Effect on Serum IgE, IL-4, IFN-γ and Quality of Life |
| 投稿时间：2018-03-15 修订日期：2018-04-12 |
| DOI：10.13241/j.cnki.pmb.2018.18.020 |
| 中文关键词: 特异性免疫疗法 慢性荨麻疹 疗效 免疫球蛋白E 白细胞介素-4 干扰素-γ 生活质量 |
| 英文关键词: Specific immunotherapy Chronic urticarial Curative effect Immunoglobulin E Interleukin-4 Interferon-γ Quality of life |
| 基金项目:陕西省自然科学基金项目（2014JQ4389） |
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| 中文摘要: |
| 摘要 目的：研究特异性免疫疗法治疗慢性荨麻疹患者的疗效及对血清免疫球蛋白E（IgE）、白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）和生活质量的影响。方法：选择2015年4月至2017年2月于陕西省人民医院进行治疗的112例慢性荨麻疹患者纳入本研究，随机分为观察组（n=56）及对照组（n=56），对照组患者给予依巴斯汀片治疗，观察组在此基础上给予特异性免疫疗法进行治疗，对比两组患者的临床疗效以及治疗前后血清IgE、IL-4、IFN-γ水平，比较两组患者治疗前后的生活质量情况。结果：观察组的总有效率为96.43%，高于对照组的83.93%（P<0.05）。治疗前，两组患者血清IgE、IL-4及IFN-γ的水平之间的差异无统计学意义（P>0.05）；治疗后，两组患者血清IgE、IL-4及IFN-γ的水平均降低，且与对照组相比，观察组各指标水平更低（P<0.05）。治疗前，两组患者的生活质量评分比较无统计学差异（P>0.05）；与治疗前比较，两组患者治疗1个月后、治疗3个月后的生活质量评分均降低，且观察组治疗1个月后、治疗3个月后的生活质量评分低于对照组（P<0.05）。结论：采用特异性免疫疗法治疗慢性荨麻疹患者疗效确切，能够降低其血清IgE、IL-4以及IFN-γ水平，改善患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative effect of specific immunotherapy on patients with chronic urticaria and its effect on serum immunoglobulin E (IgE), interleukin-4 (IL-4), interferon-γ (IFN-γ) and quality of life. Methods: 112 patients with chronic ur- ticarial treated in Shaanxi Provincial People's Hospital from April 2015 to February 2017 were selected, they were divided into the obser- vation group (n=56) and the control group (n=56) randomly. The control group were treated with Kestine, the observation group received specific immunotherapy on this basis of the control group. The clinical effects of the two groups were compared and the levels of serum IgE, IL-4, IFN-γ before and after treatment were compared, and the quality of life of the two groups before and after treatment were compared. Results: The total effective rate of the observation group was 96.43% respectively, which was higher than 83.93% in the control group(P<0.05). Before treatment, there was no significant difference between the levels of serum IgE, IL-4, IFN-γ in the two groups (P>0.05). After treatment, the levels of serum IgE, IL-4, IFN-γ in the two groups were all decreased, and compared with the control group, each index in the observation group were lower than those in the control group (P<0.05). Before treatment, there was no significant difference in the quality of life scores between the two groups (P>0.05). Compared with before treatment, the quality of life scores of the two groups decreased at one month after treatment and three months after treatment, and the observation group were lower than those in the control group (P<0.05). Conclusion: Specific immunotherapy is effective in the treatment of chronic urticaria. It can reduce the levels of serum IgE, IL-4, IFN-γ, and improve the quality of life of patients. It is worthy of clinical promotion. |
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