| 雷 飞,倪 菁,范 晶,杨 帆,姜庆生,蔡卜磊.CEA、CA125、CA-50、β2-MG对腮腺粘液表皮样癌的诊断价值分析[J].,2018,(18):3480-3484 |
| CEA、CA125、CA-50、β2-MG对腮腺粘液表皮样癌的诊断价值分析 |
| The Diagnostic Value of CEA, CA125, CA-50, β2-MG for Mucoepidermoid Carcinoma of the Parotid Gland |
| 投稿时间：2018-02-23 修订日期：2018-03-18 |
| DOI：10.13241/j.cnki.pmb.2018.18.017 |
| 中文关键词: 腮腺 粘液表皮样癌 腮腺肿瘤 诊断 |
| 英文关键词: Parotid gland Mucous epidermoid carcinoma Parotid tumor Diagnose |
| 基金项目:国家自然科学基金项目（81502338） |
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| 中文摘要: |
| 摘要 目的：探讨CEA、CA125、CA-50、β2-MG对腮腺粘液表皮样癌的诊断价值。方法：选择2015年6月至2017年5月本院收治的腮腺粘液表皮样癌患者30例为恶性肿瘤组及同期收治的良性腮腺肿瘤患者30例为良性肿瘤组，并选择30例健康体检者为健康对照组。采用酶促化学发光免疫分析法检测各组血清、混合唾液、健侧/患侧腮腺液中CEA、CA125含量；放射免疫分析法检测血清、混合唾液、健侧/患侧腮腺液中CA-50、β2-MG水平。比较各组腮腺液、唾液、血清中CEA、CA125、CA-50、β2-MG水平；分别对健侧及患侧腮腺液、混合唾液、血清中的CA-50、β2-MG水平与CEA、CA125水平进行相关性分析。结果：肿瘤组腮腺液、唾液、血清CEA水平均明显高于健康对照组(P＜0.05)，恶性肿瘤组患侧腮腺液、血清CEA水平明显高于良性肿瘤组(P＜0.05)。肿瘤组患侧腮腺液、混合唾液中CA125水平明显高于健康对照组，且恶性肿瘤组明显高于良性肿瘤组(P＜0.01)。肿瘤组各检测标本中CA-50水平均明显高于健康对照组(β2-MG水平均明显低于健康对照组)，恶性肿瘤组高于良性肿瘤组(P＜0.01)。健侧腮腺液及血清中CA-50水平与CEA水平呈显著正相关，β2-MG水平与CEA水平呈显著负相关(P＜0.05)。患侧腮腺液及混合唾液中CA-50水平与CEA、CA125水平呈显著正相关，β2-MG水平与CEA、CA125水平呈显著负相关(P＜0.05)。结论：患侧腮腺液、混合唾液中CEA、CA125、CA-50、β2-MG水平检测对腮腺粘液表皮样癌的诊断有较高的参考价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the diagnostic value of CEA, CA125, CA-50, β2-MG for mucoepidermoid carcinoma of the parotid gland. Methods: February 2012 to December 2015, 30 cases of parotid gland mucous epidermoid carcinoma patients as malignant tumor group, 30 patients with benign parotid gland tumor as benign tumor group, 30 cases of healthy people as healthy controls. The en- zyme chemiluminescence immunoassay was used to detect the levels of CEA and CA125 in the serum, mixed saliva, parotid saliva. Ra- dioimmunoassay was used to detect the levels of CA-50 and β2-MG in serum, mixed saliva, parotid saliva.The levels of CEA, CA125, CA-50 and β2-MG were compared in different groups of parotid saliva, saliva and serum. Correlation analysis was carried out on the CA-50 and β2-MG in parotid saliva, saliva and serum. Results: The level of CEA in the tumor group was significantly higher than that in the healthy control group. The level of CEA in the malignant tumor group was significantly higher than that in the benign tumor group. There were varying degrees of difference of CEA, CA125, CA-50 and β2-MG in serum, mixed saliva, parotid saliva in each group. There was significant positive correlation between the level of CA50 and CEA in healthy parotid saliva and serum, and the level of β2-MG was significantly negatively correlated with CEA, the difference was statistically significant (P<0.05). The level of CA50 in the affected parotid saliva and saliva was significantly positive correlation with CEA and CA125 level, and the level of β2-MG was signifi- cantly negative correlation with CEA and CA125, the difference was statistically significant (P<0.05). Conclusion: The explore of CEA, CA125, CA-50 and β2-MG in affected parotid saliva and saliva has high reference value in the diagnosis of parotid mucous epidermoid carcinoma. |
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