| 高 雷,龙俊宏,薛阳利,陶美华,杨妙妍,王 敏.灯盏花素注射液联合前列腺素E1对2型糖尿病肾病患者血脂及血清IL-6、TNF-α和hs-CRP水平的影响[J].,2018,(18):3476-3479 |
| 灯盏花素注射液联合前列腺素E1对2型糖尿病肾病患者血脂及血清IL-6、TNF-α和hs-CRP水平的影响 |
| Effect of Breviscapine Injection Combined with Prostaglandin E1 on the Blood Lipids, Serum IL-6, TNF-α, hs-CRP Levels of Patients with Type 2 Diabetic Nephropathy |
| 投稿时间：2017-11-28 修订日期：2017-12-23 |
| DOI：10.13241/j.cnki.pmb.2018.18.016 |
| 中文关键词: 灯盏花素注射液 前列腺素E1 2型糖尿病肾病 血脂 白细胞介素-6 肿瘤坏死因子-α C反应蛋白 |
| 英文关键词: Breviscapine injection Prostaglandin E1 Type 2 diabetic nephropathy Blood lipids Interleukin -6 Tumor necrosis factor-α C-reactive protein |
| 基金项目:陕西省科技厅攻关项目(2012K16-06-02) |
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| 中文摘要: |
| 摘要 目的：研究灯盏花素注射液联合前列腺素E1对2型糖尿病肾病患者的血脂及血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和 C反应蛋白(CPR)水平的影响。方法：收集2014年6月至2015年6月我院收治的80例2型糖尿病肾病患者，按抽签法分为实验组和对照组，每组40例。对照组采用前列腺素E1静脉滴注治疗，实验组在对照组基础上加用灯盏花素注射液治疗。观察和比较两组的治疗疗效，治疗前后血脂总胆固醇(TC)、甘油三酯(TG)、尿微量白蛋白(UAE)、血肌酐(Scr)、血清尿素氮(BUN)、IL-6、TNF-α、hs-CRP水平的变化。结果：治疗后，实验组总有效率为92.50%，显著高于对照组(72.5%，P＜0.05)；TC、TG、UAE、Scr、BUN、血清IL-6、TNF-α、hs-CRP水平均显著低于对照组(P＜0.05)；两组不良反应总发生率比较差异无统计学意义(P＞0.05)。结论：灯盏花素注射液联合前列腺素E1可显著提高2型糖尿病肾病的疗效，有效调节血脂水平，抑制炎症反应，保护肾功能，减少白蛋白漏出。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of breviscapine injection combined with Prostaglandin E1 on the blood lipids, serum in- terleukin -6(IL-6), tumor necrosis factor alpha(TNF-?), C reactive protein(hs-CRP) levels of patients with type 2 diabetic nephropathy. Methods: 80 cases of patients with type 2 diabetic nephropathy who were treated from June 2014 to June 2015 in our hospital were se- lected as research objects. According to the draw method, the patients were divided into the experimental group and the control group, with 40 cases in each group. Both groups were treated with lower urinary protein, lipid-lowering and other conventional treatment. The control group was additionally treated with prostaglandin E1 intravenous drip, while the experimental group was treated with breviscap- ine injection based on the control group. The curative effect, changes of blood lipid, total cholesterol (TC), triglyceride (TG), urinary mi- croalbumin (UAE), serum creatinine (Scr), blood urea nitrogen (BUN), IL-6, TNF-α, hs-CRP levels before and after treatment were com- pared between two groups. Results: After treatment, he total effective rate of experimental group was significantly higher than that of the control group(P＜0.05). The levels of TC and TG, UAE, Scr, BUN, serum IL-6, TNF-α, hs-CRP were significantly lower than those of the control group(P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05). Conclusion: Breviscapine injection combined with Prostaglandin E1 can significantly enhance the clinical efficacy of type 2 diabet- ic nephropathy, which can effectively adjust the level of blood lipid, reduce the expression of inflammatory factors, protect renal function and reduce albumin leakage. |
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