| 秦春霞,李 虹,张 帅,张海静,张文生.雌激素与葡萄糖能量代谢研究进展[J].,2018,(17):3388-3391 |
| 雌激素与葡萄糖能量代谢研究进展 |
| Research Advancement of Estrogen and Energy Metabolism of Glucose |
| 投稿时间：2017-12-30 修订日期：2018-01-24 |
| DOI：10.13241/j.cnki.pmb.2018.17.041 |
| 中文关键词: 雌激素 葡萄糖能量代谢 阿尔茨海默症 甲基乙二醛 活性氧 |
| 英文关键词: Estrogen Energy metabolism of glucose Alzheimer's Disease Methylglyoxal Reactive oxygen species |
| 基金项目:国家自然科学基金项目（81771152）；中央高校基本科研业务费专项资金项目(2015KJJCA05)；北京市共建项目(2017-01) |
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| 中文摘要: |
| 摘要：雌激素是类固醇激素，有雌素酮、17β-雌二醇、雌三醇3种形式，通过不同形式的雌激素受体发挥功能。雌激素影响细胞葡萄糖能量代谢，包括葡萄糖转运、糖酵解过程、三羧酸循环和氧化磷酸化作用，同时对葡萄糖能量代谢过程中副产物如甲基乙二醛、活性氧等的产生也具有重要影响。在阿尔茨海默病和肿瘤中都存在葡萄糖能量代谢异常的现象。本文针对阿尔茨海默病和肿瘤就雌激素对葡萄糖能量代谢的调节作用进行综述，以期在预防及治疗相关疾病及开发新药过程中提供新思路。 |
| 英文摘要: |
| ABSTRACT: Estrogen is a steroid hormone, including estrone, 17β-estradiol, estriol, through different forms of estrogen receptors to function. Estrogen affects cell energy metabolism of glucose, including glucose transporter, glycolysis, tricarboxylic acid cycling and oxidative phosphorylation, as well as the by-products such as methylglyoxal, reactive oxygen species in the process of energy metabolism. Abnormal energy metabolism of glucose both exists commonly in Alzheimer's Disease and tumors. This article reviews the regulatory role of estrogen on glucose in energy metabolism in Alzheimer's Disease and tumors, and offers new ideas for prevention and treatment of related diseases and development of new drugs. |
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