| 喻 敏,王慧敏,王少飞,史 捷,强宁侠.加味射干麻黄汤对重度支气管哮喘患者血清ECP、LPO、FeNO及肺功能的影响[J].,2018,(17):3315-3318 |
| 加味射干麻黄汤对重度支气管哮喘患者血清ECP、LPO、FeNO及肺功能的影响 |
| Effect of Jiawei Shegan Mahuang Decoction on serum ECP, LPO, FeNO and Lung Function in Patients with Severe Bronchial Asthma |
| 投稿时间：2018-03-28 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2018.17.024 |
| 中文关键词: 重度支气管哮喘 加味射干麻黄汤 嗜酸性粒细胞阳离子蛋白 脂质过氧化物 呼出气一氧化氮 肺功能 |
| 英文关键词: Severe bronchial asthma Jiawei Shegan Mahuang Decoction Eosinophil cationic protein Lipid peroxide Exhalation of nitric oxide Lung function |
| 基金项目:陕西省自然科学基金项目（20120539） |
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| 中文摘要: |
| 摘要 目的：探讨加味射干麻黄汤对重度支气管哮喘患者血清嗜酸性粒细胞阳离子蛋白（ECP）、脂质过氧化物（LPO）、呼出气一氧化氮（FeNO）及肺功能的影响。方法：选择2015年9月至2017年9月我院接诊的96例重度支气管哮喘患者进行研究，通过随机数表法分为观察组（n=48）和对照组（n=48），在常规治疗基础上，对照组给予异丙托溴铵溶液、甲泼尼龙琥珀酸钠治疗，观察组联合加味射干麻黄汤治疗，均连续治疗4周。比较两组临床疗效、治疗前后中医证候积分、肺功能、血清ECP、LPO及FeNO的变化和不良反应。结果：治疗后，观察组临床疗效总有效率为91.67%（44/48），明显高于对照组的72.92%（35/48）（P＜0.05）；治疗后，两组各中医证候积分、肺功能、血清ECP、LPO及FeNO较治疗前均显著改善（P＜0.05）；中医证候积分中，观察组治疗后喘息、咳嗽、咳痰、胸闷、哮鸣音积分均明显低于对照组，肺功能中，观察组第1秒用力呼出量（FEV1）、FEV1/用力肺活量（FEV1/FVC）均明显高于对照组，呼气峰值流速（PEF）昼夜变异率明显低于对照组，且观察组血清ECP、LPO及FeNO明显比低于对照组，差异均具有统计学意义（P＜0.05）；两组治疗期间不良反应比较无显著差异（P＞0.05）。结论：在重度支气管哮喘患者中应用加味射干麻黄汤效果显著，可有效改善肺功能及临床症状，其内在机制可能和调节气道慢性炎症反应、氧化应激反应，降低血清ECP、LOP及FeNO的表达相关，且用药安全性高，值得应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of Jiawei Shegan Mahuang Decoction on serum eosinophil cationic protein(ECP), lipid peroxide(LPO), exhalation of nitric oxide(FeNO) and lung function in patients with severe bronchial asthma. Methods: 96 patients of se- vere bronchial asthma who received therapy from September 2015 to September 2017 in our hospital were selected as research objects, according to random number table，those patients were divided into the observation group (n=48) and the control group (n=48), on the basis of routine treatment, the control group was treated with ipratropium bromide, methylprednisolone sodium succinate, while the ob- servation group was combined with Jiawei Shegan Mahuang Decoction, they were treated continuously for 4 weeks. The clinical efficacy and the changes of TCM syndrome score, lung function, serum ECP, LPO and FeNO before and after treatment and adverse reactionwere compared between the two groups. Results: After treatment, the total effective rate of clinical efficacy in the observation group was 91.67% (44/48), which was significantly higher than that of the control group 72.92% (35/48)(P＜0.05); after treatment, the scores of syndromes, lung function, serum ECP, LPO and FeNO between the two groups were significantly improved compared with those before the treatment(P＜0.05); in the TCM syndrome score, the scores of pant, coughin, expectoration, chest tightness, wheezing ralei in the ob- servation group were significantly lower than those in the control group, in the lung function, the 1 second forced expiratory volume (FEV1) and the forced vital capacity of FEV1/ (FEV1/FVC) in the observation group were significantly higher than those in the control group, the peak expiratory flow (PEF) diurnal variation rate was significantly lower than those in the control group, the serum ECP, LPO and FeNO in the observation group were significantly lower than those in the control group, the difference has statistical significance (P＜0.05); there was no significant difference in the adverse reaction between the two groups during the treatment(P＞0.05). Conclusion: Jiawei Shegan Mahuang Decoction is well for severe bronchial asthma, which can effectively improve the pulmonary function and clini- cal symptoms, its internal mechanism may be associated with the regulation of chronic airway inflammation, oxidative stress, and the re- duction of the expression of serum ECP, LOP and FeNO, and high safety of drug use, it is worthy of application and promotion. |
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