| 陈 爽,张 艳,陈 亮,沈鹏臻,尹 红.柳氮磺胺吡啶联合丽珠肠乐治疗溃疡性结肠炎的疗效及对患者炎症反应的影响[J].,2018,(16):3162-3166 |
| 柳氮磺胺吡啶联合丽珠肠乐治疗溃疡性结肠炎的疗效及对患者炎症反应的影响 |
| Effect of Sulfasalazine Combined with Li Zhu Chang Le in Treatment of Ulcerative Colitis |
| 投稿时间：2018-02-05 修订日期：2018-02-28 |
| DOI：10.13241/j.cnki.pmb.2018.16.036 |
| 中文关键词: 丽珠肠乐 柳氮磺胺吡啶 溃疡性结肠炎 临床疗效 炎症因子 |
| 英文关键词: Li Zhu Chang Le Sulfasalazine Ulcerative colitis Clinical efficacy Serum inflammatory factors |
| 基金项目:四川省自然科学基金项目（2015FZ0457） |
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| 中文摘要: |
| 摘要 目的：观察丽珠肠乐联合柳氮磺胺吡啶治疗溃疡性结肠炎的疗效及对患者炎症反应的影响。方法：选取我院2014年6月-2017年6月期间收治的溃疡性结肠炎患者120例，根据数表法将患者分为观察组（n=60）和对照组（n=60）。对照组采用柳氮磺胺吡啶治疗，观察组在对照组的基础上增加丽珠肠乐治疗。连续治疗8周后观察两组患者的临床疗效以及结肠炎症状改善程度，并对两组患者治疗前后的血清炎症因子水平进行检测对比，同时观察两组患者不良反应发生情况。结果：观察组临床治疗的总有效率为93.33%（56/60），高于对照组的80.00%（48/60）（P<0.05）。治疗后两组患者Sutherland指数评分、肠道菌群评分、肠镜评分均低于治疗前，且观察组低于对照组（P<0.05）。治疗后两组患者CRP、IL-6、TNF-α水平均低于治疗前，且观察组低于对照组（P<0.05）。观察组不良反应发生率为13.33%（8/60），与对照组的8.33%（5/60）比较差异无统计学意义（P>0.05）。结论：柳氮磺胺吡啶联合丽珠肠乐治疗溃疡性结肠炎的临床疗效显著，能够改善患者的临床症状，降低患者体内的炎症因子水平，且无严重不良反应发生，临床应用价值高，值得进一步推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of sulfasalazine combined with Li Zhu Chang Le in the treatment of ulcerative colitis and its influence on the inflammatory reaction. Methods: A total of 120 patients with ulcerative colitis, who were treated in Zigong Fourth People's Hospital from June 2014 to June 2017 were selected and randomly divided into observation group (n=60) and control group (n=60). The control group was treated with sulfasalazine, and the observation group were treated with Li Zhu Chang Le on the basis of the control group's therapy. After 8 weeks of continuous treatment, the clinical efficacy of the two groups and the improvement of the symptoms of colitis were observed, and the levels of serum inflammatory factors before and after treatment were compared between the two groups, at the same time, the incidence of adverse reactions in the two groups was observed. Results: The total effective rate(93.33%) of clinical treatment of the observation group was higher than that(80.00%) of the control group (P<0.05). The scores of Sutherland index, intestinal flora and enteroscopy after treatment were lower than those before treatment, and the indexes of the observation group were lower than those of the control group (P<0.05). The levels of CRP, IL-6 and TNF-α of the two groups after treatment were lower than those before treatment, and the indexes of the observation group were lower than those of the control group (P<0.05). The incidence of adverse reactions in the observation group and the control group was 13.33% (8/60) and 8.33% (5/60), respectively, in which, there was no significant difference between the two groups (P>0.05). Conclusion: The clinical curative effect of Salazonazine combined with Li Zhu Chang Le in the treatment of ulcerative colitis is better, without serious adverse reaction and with high value of clinical application, which is worthy of further popularization and application. |
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