| 李京娜,解裕豆,王 霄,闫丛丛,朱彤宇.地特胰岛素联合二甲双胍治疗妊娠糖尿病的疗效及对患者血清内脂素、抵抗素、血脂水平的影响[J].,2018,(16):3098-3101 |
| 地特胰岛素联合二甲双胍治疗妊娠糖尿病的疗效及对患者血清内脂素、抵抗素、血脂水平的影响 |
| Efficacy of Insulin Detemir and Metformin in the Treatment of Gestational Diabetes Mellitus and Its Effects on the Serum Visfatin, Resistin and Blood Lipid Levels |
| 投稿时间：2018-04-05 修订日期：2018-04-30 |
| DOI：10.13241/j.cnki.pmb.2018.16.021 |
| 中文关键词: 地特胰岛素 二甲双胍 妊娠糖尿病 内脂素 抵抗素 |
| 英文关键词: Insulin detemir Metformin Gestational diabetes mellitus Visfatin Resistin |
| 基金项目:山东省卫生厅科研基金项目（2009HZ167） |
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| 中文摘要: |
| 摘要 目的：研究地特胰岛素联合二甲双胍治疗妊娠糖尿病的临床疗效及对患者血清内脂素、抵抗素、血脂水平的影响。方法：选择2016年10月至2017年10月在我院进行治疗的妊娠糖尿病患者120例，按照随机数表法分为观察组和对照组。对照组给予二甲双胍治疗，观察组以对照组为基础联合地特胰岛素治疗。治疗后，观察和两组的临床疗效及不良反应的发生情况，治疗前后血清内脂素、抵抗素水平以及血脂血糖水平的变化。结果：治疗后，观察组总有效率(96.67%)明显高于对照组(85.00%)(P<0.05)；观察组血清内脂素、抵抗素、总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖及餐后2h血糖水平均显著低于对照组(P<0.05)，HDL-C水平明显高于对照组(P<0.05)；两组不良反应发生率比较差异无统计学意义(P>0.05)。结论：与单用二甲双胍相比，地特胰岛素联合二甲双胍治疗妊娠糖尿病可有效调节患者血脂血糖水平，降低血清内脂素与抵抗素水平，从而显著提高临床疗效，且安全性较好。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative efficacy of insulin detemir and metformin in the treatment of gestational diabetes mellitus and their effects on the serum visfatin, resistin and blood lipid levels. Methods: 120 cases of patients with gestational diabetes mellitus who were treated in our hospital from October 2016 to October 2017 were selected as the research objects, they were divided into the observation group and the control group according to the random number table method, the control group was treated with metformin, the observation group was treated with insulin detemir on the basis of control group. After treatment, the clinical effects, incidence of adverse reactions, changes of serum visfatin, resistin, blood lipid, blood glucose levels were compared between two groups. Results: After treatment, the total effective rate of observation group (96.67%) was significantly higher than that of the control group (85.00%) (P<0.05); the serum visfatin, resistin levels of observation group were lower than those of the control group(P< 0.05); the serum TC, TG, LDL-C levels of observation group were lower than those of the control group, the serum HDL-C level was higher than that of the control group, the FBG and 2hPG levels of observation group was lower than those of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Insulin detemir and metformin can effectively adjust the blood lipid and glucose levels, reduce the fat grain and resistin levels in the serum, significantly improve the clinical curative effect with good security in the treatment of gestational diabetes mellitus. |
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