| 胡全福,欧阳绍基,姚榕威,张丽丽,徐学江.等离子射频消融术治疗儿童腺样体肥大的疗效观察及对患儿通气功能和炎症反应的影响[J].,2018,(16):3084-3088 |
| 等离子射频消融术治疗儿童腺样体肥大的疗效观察及对患儿通气功能和炎症反应的影响 |
| Effect of Plasma Radiofrequency Ablation on the Adenoid Hypertrophy in Children and Its Influence on the Ventilation and Inflammatory Reaction |
| 投稿时间：2017-12-27 修订日期：2018-01-31 |
| DOI：10.13241/j.cnki.pmb.2018.16.018 |
| 中文关键词: 等离子射频消融术 儿童腺样体肥大 疗效 通气功能 炎症反应 |
| 英文关键词: Plasma radiofrequency ablation Adenoid hypertrophy in children Curative effect Ventilatory function Inflammatory reaction |
| 基金项目:南方医科大学第五附属医院院长基金项目（YZ2017QN002） |
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| 中文摘要: |
| 摘要 目的：探讨等离子射频消融术治疗儿童腺样体肥大的临床疗效及对患儿通气功能和炎症反应的影响。方法：选取我院2016年12月至2017年8月治疗的腺样体肥大患儿100例为研究对象，其中50例手术治疗者为等离子组，同期保守药物治疗者50例为对照组。对照组给予孟鲁司特钠、糠酸莫米松鼻喷雾剂治疗，等离子组行低温等离子射频消融术。比较两组治疗前后症状积分、通气功能、炎症因子水平的变化。结果：治疗前，两组症状积分、通气功能指标呼吸紊乱指数(apnea hypopnea index, AHI)、最长呼吸暂停时间(longest apnea time, LAT)、氧减指数(oxygen reduction index, ODI)、最低夜间血氧饱和度(lowest nocturnal oxygen saturation, LSaO2)、血氧饱和度小于90%时间所占睡眠时间百分比(percentage of time when oxygen saturation lower than 90%, SLT90 %)以及血清肿瘤坏死因子-α (inflammatory mediators of tumor necrosis factor, TNF-α)、白介素-4(interleukin, IL-4)、嗜酸细胞阳离子蛋白(eosinophil cationic protein, ECP)水平比较差异均无统计学意义(P>0.05)。治疗后，两组打鼾、鼻塞、张口呼吸等症状积分与治疗前相比均显著降低(P<0.05)，且等离子组打鼾、鼻塞、张口呼吸各项积分均显著低于对照组(P<0.05)。治疗后，两组AHI、LAT、ODI、SLT90 %、血清TNF-α、ECP、IL-4水平均较治疗前显著降低(P<0.05)，LSaO2水平均较治疗前显著升高(P<0.05)，且等离子组AHI、LAT、ODI、SLT90 %、血清TNF-α、ECP、IL-4水平均显著低于对照组，LSaO2水平显著高于对照组(P<0.05)。结论：低温等离子射频消融术可显著缓解儿童腺样体肥大患儿的临床症状，改善机体通气功能，减轻炎症反应。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the curative effect of plasma radiofrequency catheter ablation on adenoid hypertrophy in children and its effect on ventilatory function and inflammatory response. Methods: 100 cases of adenoid hypertrophy in our hospital from December 2016 to August 2017 were selected, 50 cases patienta treated with surgical treatment was in plasma group, and 50 patients treated with conservative treatment were in control group in the same period. The control group was given montelukast and Mumetasone furfurfurate nasal spray, and the plasma group was given low temperature plasma radiofrequency ablation. The symptom score, ventilation function and inflammatory cytokines levels in two groups before and after treatment were compared. Results: Before treatment, symptom score, apnea hypopnea index (AHI), longest apnea time (LAT), oxygen reduction index (ODI), minimum nocturnal oximetry Lowest nocturnal oxygen saturation (LSaO2), percentage of time when oxygen saturation less than 90% (SLT 90%), and serum inflammatory mediators (TNF-α), interleukin-4 (IL-4) and eosinophil cationic protein (ECP) levels were not significantly different between the two groups (P>0.05). After treatment, the scores of snoring, nasal obstruction and mouth breathing were significantly decreased in both groups (P<0.05), and the scores of snoring, nasal obstruction and mouth breathing in plasma group were significantly lower than those in control group (P<0.05). After treatment, the levels of AHI, LAT, ODI and SLT90 % in both groups were significantly decreased (P<0.05), and the LSaO2 level was significantly increased (P<0.05). After treatment, the levels of AHI, LAT, ODI, SLT90 % in the plasma group were significantly lower than those in the control group (P<0.05), and the LSaO2 level was significantly higher than the control group (P<0.05). Conclusion: Low-temperature plasma radiofrequency ablation can significantly relieve the clinical symptoms of children, improve the body's ventilatory function and reduce the inflammatory response. |
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