| 李晓黎,王 磊,刘 璐,徐则林,刘 畅.镁离子联合金雀异黄素对自发性高血压大鼠血压的影响[J].,2018,(16):3032-3035 |
| 镁离子联合金雀异黄素对自发性高血压大鼠血压的影响 |
| Effect of Magnesium Ion Combined with Genistein on Blood Pressure in Spontaneously Hypertensive Rats |
| 投稿时间：2018-03-06 修订日期：2018-03-31 |
| DOI：10.13241/j.cnki.pmb.2018.16.007 |
| 中文关键词: 镁离子 金雀异黄素 自发性高血压大鼠 血管 |
| 英文关键词: Magnesium ion Genistein SHR Blood vessel |
| 基金项目:国家自然科学基金项目(81271288) |
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| 中文摘要: |
| 摘要 目的：探讨镁离子联合金雀异黄素对自发性高血压大鼠血压的影响。方法：选用雌性6周自发性高血压大鼠28只，饲养7d后测量大鼠初始收缩压(SBP)及心率(HR)，应用双盲分组原则，将大鼠分成对照组、镁离子组、金雀异黄素组、及联合组，每组各7只。饲养7d后，取一次性注射器，消毒抽取药物，暴露尾部及血管，进行注射。每7d注射一次，连续注射4周。比较各组大鼠SBP、HR、hs-CRP、MCP-1、vWF、血管紧张素(AngⅡ)。结果：给药前四组大鼠SBP水平比较无差异(P>0.05)。给药后对照组SBP水平高于其他三组(P<0.05)，镁离子组与金雀异黄素组比较无差异(P>0.05)，联合组大鼠在给药1周、2周、4周后SBP水平显著低于其他三组(P<0.05)。给药前四组大鼠心率比较无差异(P>0.05)。给药后对照组、镁离子组、金雀异黄素组与治疗前相比无差异(P>0.05)，联合组低于治疗前(P<0.05)。给药第2、4周联合组HR水平低于其他三组(P<0.05)。联合大鼠hs-CRP水平显著降低(P<0.05)，MCP-1、vWF水平显著升高(P<0.05)。给药前各组大鼠AngⅡ水平比较无差异(P>0.05)，给药2周、4周联合组AngⅡ水平显著降低(P<0.05)。结论：镁离子联合金雀异黄素能提高自发性高血压大鼠血管顺应性，减少炎症反应，预防动脉粥样硬化，降低血压。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of magnesium ion combined with genistein on blood pressure in spontaneously hypertensive rats (SHR). Methods: Twenty-eight female SHR were selected for 6 weeks. 7d after feeding, the initial systolic blood pressure (SBP) and heart rate (HR) of rats were measured. The SHRs were divided into control group, the magnesium ion group, the genistein group and the combined group according to the double-blind, each with 7 cases. After 7d, the rats received drug injection once a week for 4 weeks. Then the SBP, HR, hs-CRP, MCP-1, vWF and angiotensinⅡ (AngⅡ) in rats were compared. Results: The SBP level between the four groups before administration had no significant difference (P>0.05); After administration, SBP level in the control group was higher than that in the other three groups (P<0.05), no difference was found between magnesium ion group and genistein group (P>0.05), moreover the combined group was significantly lower than that in the other three groups at the 1 week,2 weeks and 4 weeks after administration (P<0.05); the HR before administration had no significant difference (P>0.05); after administration, no significant changes except combined group occurred (P>0.05), the HR in the combined group decreased (P<0.05), and was lower than that in the other three groups at 2 weeks and 4 weeks after administration (P<0.05); The hs-CRP levels in the combined group were significantly lower than those in the other three groups (P<0.05), and the levels of MCP-1 and vWF were higher in the combined group than in the other three groups (P<0.05); the levels of AngⅡ in the four groups showed no significant difference before administration (P>0.05), and the levels of AngⅡ in the combined group were lower than those in the other three groups (P<0.05). Conclusion: Magnesium ion combined with genistein can improve vascular compliance in SHR, reduce the inflammatory response, prevent atherosclerosis and lower blood pressure. |
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