| 吴琳虹,张 萌,陈兴强,韦明辉,符薇薇.阿托伐他汀联合厄贝沙坦对老年早期糖尿病肾病患者肾功能及微炎症状态的影响[J].,2018,(15):2962-2965 |
| 阿托伐他汀联合厄贝沙坦对老年早期糖尿病肾病患者肾功能及微炎症状态的影响 |
| Effect of Atorvastatin Combined with Irbesartan on Renal Function and Micro Inflammatory State in Elderly Patients with Early Diabetic Nephropathy |
| 投稿时间：2017-11-27 修订日期：2017-12-23 |
| DOI：10.13241/j.cnki.pmb.2018.15.036 |
| 中文关键词: 阿托伐他汀 厄贝沙坦 糖尿病肾病 肾功能 微炎症 |
| 英文关键词: Atorvastatin Irbesartan Diabetic nephropathy Renal function Micro inflammation |
| 基金项目:海南省卫生厅科学研究项目（琼卫2013PT-127） |
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| 中文摘要: |
| 摘要 目的：探讨阿托伐他汀联合厄贝沙坦对老年早期糖尿病肾病（DN）患者肾功能及微炎症状态的影响。方法：选取2016年4月到2017年2月在我院肾内科接受治疗的老年早期DN患者84例，根据随机数字表法将患者分为对照组和观察组，各42例。对照组给予厄贝沙坦进行治疗，观察组给予阿托伐他汀联合厄贝沙坦进行治疗。比较两组患者的尿微量白蛋白排泄率（UAER）及两组患者血肌酐（Scr）、血尿素氮（BUN）、β2微球蛋白（β2-MG）、白细胞介素-1（IL-1）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）水平，并比较两组患者治疗过程中出现的不良反应。结果：治疗后两组患者的UAER、Scr、BUN、β2-MG水平均降低，且观察组的UAER、Scr、BUN、β2-MG均低于对照组（P<0.05）。治疗后两组患者血清中IL-1、TNF-α水平均降低，IL-10水平升高（P<0.05）；治疗后观察组血清中IL-1、TNF-α水平低于对照组，IL-10水平高于对照组（P<0.05）。两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：阿托伐他汀联合厄贝沙坦对老年早期DN患者有较好的治疗效果，可显著改善患者的肾功能，减轻微炎症状态，且安全性较好，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of Atorvastatin combined with irbesartan on renal function and micro inflammatory state in elderly patients with early diabetic nephropathy(DN). Methods: 84 elderly patients with DN who were treated in the department of nephrology of our hospital from April 2016 to February 2017, and the patients were divided into the control group and the observation group according to the random number table method, 42 cases in each group. The control group was treated with irbesartan, and the ob- servation group was treated with Atorvastatin combined with irbesartan.Urinary albumin excretion rate(UAER) and the levels of serum creatinine (Scr), blood urea nitrogen (BUN), β2 microglobulin(β2-MG), interleukin-1(IL-1), interleukin-10(IL-10), tumor necrosis fac- tor-α(TNF-α) of patients in two groups were compared, and the adverse reactions in the two groups were compared between the two groups. Results: After treatment, the levels of UAER, Scr, BUN, β2-MG of patients in the two groups were decreased, and UAER, Scr, BUN, β2-MG in the observation group were lower than that in the control group(P<0.05). After treatment, the levels of serum IL-1 and TNF-α were decreased in the two groups, and the level of IL-10 was increased(P<0.05), after treatment, the levels of serum IL-1 and TNF-α in the observation group were lower than that in the control group, and the level of IL-10 in the observation group was higher than that in the control group (P<0.05). The incidence of adverse reactions in the two groups was not statistically significant(P>0.05). Conclusion: Atorvastatin combined with irbesartan is effective in the treatment of elderly patients with early DN, it can significantly improve the patient's renal function, reduce the micro inflammatory state, and the safety is good, which is worthy of clinical application. |
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