| 刘影哲,温宇婷,闫博馨,丁家喻,王 雪,潘祥宾.苏木对糖尿病大血管病变中SOD、TNF-α、MCP-1的影响[J].,2018,(14):2637-2640 |
| 苏木对糖尿病大血管病变中SOD、TNF-α、MCP-1的影响 |
| Effect of Caesalpinia Sappan on the Serum SOD, TNF-α, MCP-1 Levels in Rats with Diabetic Macroangiopathy |
| 投稿时间：2017-12-30 修订日期：2018-01-27 |
| DOI：10.13241/j.cnki.pmb.2018.14.007 |
| 中文关键词: 苏木 糖尿病大血管病变 Superoxide dismutase Tumor necrosis factor-α monocyte chemoattractant protein-1 |
| 英文关键词: Caesalpinia sappan Diabetic macroangiopathy SOD TNF-α MCP-1 |
| 基金项目:黑龙江省博士后科研启动基金项目（LBH-Q13168） |
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| 中文摘要: |
| 摘要 目的：探讨苏木对糖尿病大血管病变大鼠血清超氧化物歧化酶(SOD)、肿瘤坏死因子α(TNF-α)、单核细胞趋化因子1(MCP-1)水平的影响。方法：将24只雄性SD大鼠随机分为4组，每组6只，分别为对照组、模型组、α-硫辛酸组和苏木组。除去对照组，余下的18只大鼠单次腹腔注射STZ50 mg/kg制备糖尿病大鼠模型，对照组予以注射等体积的柠檬酸-柠檬酸钠缓冲液。成功造模后，苏木组给予0.15 g/kg/d的苏木，α-硫辛酸组给予20 mg/kg/d的α-硫辛酸，每日1次给药，连续给药8周。8周末，检测和比较两组大鼠血清中SOD、TNF-α、MCP-1水平的变化。结果：治疗后，苏木组及α-硫辛酸组血清SOD含量均高于模型组(P<0.05)，但苏木组和α-硫辛酸组组间比较无统计学差异(P >0.05)；苏木组及α-硫辛酸组血清TNF-α、MCP-1含量均显著低于模型组(P<0.05)，与对照组没有明显差别(P >0.05)。结论：苏木可提高糖尿病大血管病大鼠血清SOD含量，降低血清TNF-α、MCP-1含量。 |
| 英文摘要: |
| ABSTRACT Objective: Investigate the effect of Caesalpinia sappan on the levels of serum superoxide dismutase (SOD), tumor necrosis factor (TNF-α and monocyte chemokine (MCP-1) in diabetic rats with macrovascular disease. Methods: 24 male rats were ran- domly divided into 4 groups, 6 rats in each group, the control group, the model group, the α-lipoic acid group and the Caesalpinia sap- pan group, respectively. Except the control group, STZ50 mg/kg was injected intraperitoneally in other three groups. The control group was injected with equal volume of citric acid sodium citrate buffer. After successful molding, the Caesalpinia sappan group was given 0.15 g/kg/d of Caesalpinia sappan, α-lipoic acid group was given alipoic acid of 20 mg/kg/d, the drug was given 1 times a day for 8 weeks. After 8 weeks, the changes of SOD, TNF -α, MCP-1 in serum of two groups of rats were detected and compared. Results: After treatment, the contents of serum SOD in Caesalpinia sappan group and α-lipoic acid group were higher than those in model group. (P<0.05), there was no statistical difference between two groups yet(P>0.05). The level of serum TNF -α and MCP-1 were significantly lower in the Caesalpinia sappan group and α-lipoic acid group than those in the model group(P<0.05), but there was no obvious differ- ence comparing with the control group (P>0.05). Conclusion: Caesalpinia sappan can increase the content of SOD and decrease the con- tent of TNF-α and MCP-1 in the serum of diabetic rats with macrovascular disease. |
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