| 余 谦,卿 秀,尧逢友,戴宏勋,刘 波.原发性高血压患者Hcy、hs-CRP及IL-6水平与血压变异性的相关性研究[J].,2018,(12):2279-2282 |
| 原发性高血压患者Hcy、hs-CRP及IL-6水平与血压变异性的相关性研究 |
| Correlation of Hcy, hs-CRP and IL-6 Levels with Blood Pressure Variability in Patients with Primary Hypertension |
| 投稿时间：2018-03-09 修订日期：2018-03-31 |
| DOI：10.13241/j.cnki.pmb.2018.12.016 |
| 中文关键词: 原发性高血压 血压变异性 同型半胱氨酸 超敏C反应蛋白 白细胞介素-6 相关性 |
| 英文关键词: Primary hypertension Blood pressure variability Homocysteine Hypersensitive c-reactive protein Interleukin-6 Corre- lation |
| 基金项目:四川省卫生和计划生育委员会科研项目（150341） |
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| 中文摘要: |
| 摘要 目的：研究原发性高血压患者同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）及白细胞介素-6（IL-6）水平与血压变异性的相关性。方法：选取2016年2月-2017年12月四川大学华西医院收治的180例原发性高血压患者为研究对象。将所有患者根据Hcy水平的不同分为Ⅰ组80例、Ⅱ组61例、Ⅲ组39例。根据hs-CRP水平的不同分为A组71例、B组68例、C组41例。根据IL-6水平的不同分为D组80例、E组61例、F组39例。对比不同Hcy、hs-CRP以及IL-6水平患者的血压变异性及空腹血糖情况，分析Hcy、hs-CRP及IL-6水平与血压变异性的相关性。结果：不同Hcy水平患者中Ⅱ组、Ⅲ组的24hSSD、24hDSD水平高于Ⅰ组，且Ⅲ组高于Ⅱ组（P<0.05）。不同hs-CRP水平患者中B组、C组的24hSSD、24hDSD水平高于A组，且C组高于B组（P<0.05）。不同IL-6水平患者中E组、F组的24hSSD、24hDSD水平高于D组，且F组高于E组（P<0.05）。不同Hcy、hs-CRP以及IL-6水平患者空腹血糖水平比较差异无统计学意义（P>0.05）。经Pearson相关性分析显示，Hcy、hs-CRP及IL-6水平与24hSSD、24hDSD水平均呈正相关（P<0.05）。结论：原发性高血压患者Hcy、hs-CRP及IL-6水平与血压变异性存在明显正相关，对空腹血糖无明显影响，值得临床重点关注。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation of Homocysteine (Hcy), Hypersensitive C reactive protein (hs-CRP) and Inter- leukin -6 (IL-6) levels with blood pressure variability in patients with primary hypertension. Methods: A total of 180 patients with primary hypertension, who were admitted to West China Hospita of Sichuan University from February 2016 to December 2017, were selected and were divided into group Ⅰ(n=80), group Ⅱ(n=61), group Ⅲ (n=39) according to the difference of Hcy levels; all the patients were di- vided into group A (n=71), group B (n=61), group C (n=41)according to the difference of hs-CRP level; all the patients were divided into group D (n=80), group E (n=61), group F (n=39) according to the difference of IL-6 level. Blood pressure variability and fasting blood glucose in the patients with different Hcy, hs-CRP and IL-6 levels were compared; the correlation between Hcy, hs-CRP and IL-6 levels and blood pressure variability were analyzed. Results: The levels of 24hSSD and 24hDSD in group II and group III among the patients with different Hcy levels were higher than those in group I, and group III was higher than group II (P<0.05). The levels of 24hSSD and 24hDSD in group B and group C among the patients with different hs-CRP levels were higher than those in group A, and group C was higher than group B (P<0.05). The levels of 24hSSD and 24hDSD in group E and group F among the patients with different IL-6 levels were higher than group D, and group F was higher than group E (P<0.05). There were no significant differences in the level of fasting blood glucose among the patients with different Hcy, hs-CRP and IL-6 levels (P>0.05). The Pearson correlation analysis showed that the levels of Hcy, hs-CRP and IL-6 were positively correlated with the levels of 24hSSD and 24hDSD (P<0.05). Conclusion: The levels of Hcy, hs-CRP and IL-6 in the patients with primary hypertension are positively correlated with blood pressure variability, and there is no obvi- ous effect on fasting blood glucose, which is worthy of clinical focus. |
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