| 徐新利,王 敏,李学云,詹海梁,马松峰.先天性心脏病患儿围术期输血与术后肺损伤的相关性研究[J].,2018,(11):2150-2153 |
| 先天性心脏病患儿围术期输血与术后肺损伤的相关性研究 |
| Correlation between of Perioperative Blood Transfusion and Postoperative Lung Injury in Children with Congenital Heart Disease |
| 投稿时间：2018-01-08 修订日期：2018-01-31 |
| DOI：10.13241/j.cnki.pmb.2018.11.032 |
| 中文关键词: 先天性心脏病 围术期输血 术后肺损伤 相关性 |
| 英文关键词: Congenital heart disease Perioperative blood transfusion Postoperative lung injury Correlation |
| 基金项目:新疆维吾尔自治区卫生计生委科研项目（2016Y16） |
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| 中文摘要: |
| 摘要 目的：研究先天性心脏病患儿围术期输血与术后发生肺损伤的相关性。方法：选择我院诊治的120例先天性心脏病患儿，均在体外循环下进行手术矫治。根据患儿术后是否出现肺损伤分为无肺损伤组(n=97例)与肺损伤组(n=23例)。比较两组一般资料，比较不同围术期输血浆量及输血量患儿的术后肺损伤发病率；采用多因素logistic回归对术后肺损伤与围术期输血浆量、围术期输血量、最低红细胞压积(>30%)、体外循环时间(>80 min)、年龄(≤1岁)以及最低温度之间的相关性进行分析。结果：无肺损伤组与肺损伤组患儿性别间无显著差异(P>0.05)；肺损伤组患儿年龄、体质量均显著低于无肺损伤组患儿(P<0.05)，而围术期输血浆量、围术期输血量、最低血红积压、体外循环时间均显著高于无肺损伤组患儿(P<0.05)。随着患儿围术期输血浆量及输血量的增加，患儿术后肺损伤的发病率越高(P<0.05)；多因素logistic回归分析显示围术期输血浆量、围术期输血量、最低红细胞压积(>30%)、体外循环时间(>80 min)以及年龄(≤1岁)是患儿发生术后肺损伤的独立危险因素(P<0.05)。结论：围术期输血浆量以及输血量与先天性心脏病患儿术后肺损伤的发生紧密相关，围术期输血浆量以及输血量越多，肺损伤的发生风险就越高，建议临床上开展多种节约用血措施。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between perioperative blood transfusion and postoperative lung injury in children with congenital heart disease. Methods: 120 cases of congenital heart disease in our hospital were selected and undergone surgical correction under cardiopulmonary bypass. According to whether there was postoperative lung injury in children with no lung injury group (n=97 cases) and lung injury group (n=23 cases). The general information of two groups was compared. To observe the incidence of postoperative lung injury in children with different perioperative blood transfusion volume and transfusion volume. Multivariate logistic regression was used to evaluate the postoperative lung injury and perioperative blood transfusion volume, perioperative blood transfusion volume, minimum hematocrit (>30%), cardiopulmonary bypass time (>80 min), age (≤1 year old). The correlation between the lowest temperature was analyzed. Results: There was no significant difference in sex between children without lung injury and those with lung injury (P>0.05). The age and body weight of children with lung injury were significantly lower than those without lung injury (P<0.05) Blood transfusion volume, perioperative blood transfusion volume, minimum red blood pressure, and cardiopulmonary bypass time were significantly higher than those without lung injury (P<0.05). With the perioperative blood transfusion volume and blood transfusion increased, the incidence of postoperative lung injury in children was higher (P<0.05). Multivariate logistic regression analysis showed that perioperative blood transfusion volume, perioperative blood transfusion, minimum hematocrit (>30%), cardiopulmonary bypass time (>80 min) and age Indirect risk factors for lung injury (P<0.05). Conclusion: Perioperative blood transfusion volume and blood transfusion are closely related to the occurrence of postoperative lung injury in children with congenital heart disease. Perioperative blood transfusion and the amount of blood transfusion, the higher the risk of lung injury. Proposed to carry out a variety of clinical blood conservation measures. |
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