| 李 丹,郑文武,廖双华,王云鹏,陈雨露.女性冠心病患者胆红素血脂综合指数、ApoB水平与冠状动脉病变程度的相关性研究[J].,2018,(11):2114-2117 |
| 女性冠心病患者胆红素血脂综合指数、ApoB水平与冠状动脉病变程度的相关性研究 |
| Correlation of the Bilirubin Blood Lipid Comprehensive Index and Apolipoprotein B with the Severity of Coronary Lesions in Female Patients with Coronary Artery Disease |
| 投稿时间：2017-12-12 修订日期：2018-01-05 |
| DOI：10.13241/j.cnki.pmb.2018.11.024 |
| 中文关键词: 胆红素血脂综合指数 ApoB 女性 冠心病 |
| 英文关键词: Bilirubin blood lipid comprehensive index Apolipoprotein B Female Coronary artery disease |
| 基金项目:四川省科技厅支撑计划项目(14ZC0066)；四川省卫生厅科研项目（110375） |
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| 中文摘要: |
| 摘要 目的：研究女性冠心病患者胆红素血脂综合指数、ApoB水平与冠脉病变程度的关系。方法：选取2016年1月-2016年12月于我院行冠状动脉造影检查的女性患者共246例，按照两种不同方法分组：(1)按照冠状动脉造影结果分为冠心病组(n=105)和正常对照组(n=141)；(2)按照Gensini评分系统定量评估所有冠心病患者的冠状动脉病变程度，分为第1四分位组(n=35)、第2四分位组(n=32)、第3四分位组(n=39)及第4四分位组(n=35)。测定所有患者的血清总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A/B(Apo A/B)水平，计算胆红素血脂综合指数[TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)]。结果：(1)冠心病组TC、TG、LDL-C、ApoB较正常组高，HDL-C、ApoA、TBIL、DBIL、IBIL较正常组低，差异有统计学意义(P＜0.05)；与正常组相比，冠心病组胆红素血脂综合指数[TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)]升高，差异有统计学意义(P＜0.05)。(2)在不同Gensini评分四分位组中，TC、LDL-C、Apo B、TBIL、DBIL、IBIL、TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)的差异均有统计学意义(P<0.05)。(3)相关性分析显示：TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)、ApoB均与冠脉不同Gensini评分呈正相关(r=0.538，P＜0.05；r=0.670，P＜0.05；r=0.462，P＜0.05)；TBIL、DBIL、IBIL与冠脉不同Gensini评分呈负相关(r=-0.485，P＜0.05；r=-0.564，P＜0.05；r=-0.359，P＜0.05)。结论：(1)女性冠心病患者血脂胆红素综合指数、ApoB较正常对照组患者显著升高，而TBIL、DBIL、IBIL降低；(2)女性冠心病患者胆红素血脂综合指数、ApoB水平与其冠脉病变程度呈显著正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between Bilirubin blood lipid Comprehensive index and apolipoprotein B and the severity of coronary lesions of female patients with coronary artery disease(CAD). Methods: A total of 246 cases of female patients with coronary angiography were divided into 2 sets of groups. ①According to the results of coronary angiography, the female patients were divided into the CAD group(n=141) and normal control group(n=105); ②By Gensini scoring system, the female patients were divided into 4 quartile groups: 1st quartile group(n=35), 2nd quartile group(n=32), 3rd quartile group(n=39) and 4th quartile group(n=35). The blood level of total bilirubin(TBIL), direct bilirubin(DBIL), indirect bilirubin(IBIL), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), apolipoprotein A/B(Apo A/B) level were measured. Bilirubin blood lipid Comprehensive index[TC/ (HDL-C+TBIL), LDL-C/ (HDL-C+TBIL)] were calculated. Results: ①The levels of TC, TG, LDL-C and ApoB in CAD group were higher than those of the normal control group; the HDL-C, ApoA, TBIL, DBIL and IBIL were lower than those of the normal control group(P<0.05); Compared with the normal group, the ratios of TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) were increased(P＜0.05). ②By Gensini scoring system, the level of TC, LDL-C, ApoB, TBIL, DBIL, IBIL, ratios of TC/(HDL-C+TBIL) and LDL-C/(HDL-C+TBIL) were different among 4 groups(P＜0.05). ③Correlation analysis showed that TC/(HDL-C+TBIL), LDL-C/ (HDL-C+TBIL) and ApoB were positively related to Gensini scoring system(r=0.538, P＜0.05; r=0.670, P＜0.05 and r=0.462, P＜0.05). But TBIL, DBIL, IBIL were negatively related to Gensini scoring system(r=-0.485, P＜0.05; r=-0.564, P＜0.05 and r=-0.359, P＜0.05). Conclusion: ①Bilirubin blood lipid Comprehensive index and apolipoprotein B were significantly higher than the control group, while TBIL, DBIL, IBIL decreased.②Bilirubin blood lipid Comprehensive index and apolipoprotein B were positively related to the severity of coronary artery lesions of female CAD patients. |
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