| 张湘宜,任娅岚,陈思思,钱丽萍,李景星,刘亚丽.细胞共培养在牙周膜干细胞相关研究中的应用[J].,2018,(8):1588-1591 |
| 细胞共培养在牙周膜干细胞相关研究中的应用 |
| Application of Cell Co-culture Technique in Periodontal Ligament Stem Cells |
| 投稿时间：2017-09-16 修订日期：2017-10-10 |
| DOI：10.13241/j.cnki.pmb.2018.08.040 |
| 中文关键词: 细胞共培养 牙周膜干细胞 免疫调节 定向分化 牙周组织工程 |
| 英文关键词: Cell co-culture Periodontal ligament stem cells Immunomodulation Oriented differentiation Periodontal tissue engineering |
| 基金项目:国家自然科学基金项目（31301067）；教育部博士点研究基金项目（20135317120005）；云南省研究基金和科技人才计划项目（2013Z106, 2015HB044, D-201667） |
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| 中文摘要: |
| 摘要：细胞共培养是一种将不同种类、不同来源的细胞在同一个体系中进行培养、增殖的技术，在细胞间的相互作用、细胞信号转导、细胞功能性间隙连接等方面的研究中有重要作用。近年来，随着组织工程学和干细胞技术的飞速发展，牙周膜干细胞(periodontal ligament stem cells, PDLSCs)已成为研究热点之一。将PDLSCs与不同的细胞共培养, 可研究其免疫调节机制及定向分化作用；在牙周组织工程中，则可为组织修复材料的研究提供技术支持。故本文对目前细胞共培养技术在PDLSCs研究中的应用做一简要综述。 |
| 英文摘要: |
| ABSTRACT: Cell co-culture is a technique that can be cultured and proliferated in the same system with the cells of different types and different sources, and it plays a key role in the study of the interaction between cells, cell signal transduction, cell functional gap junctions and so on. In recent years, with the rapid development of tissue engineering and stem cell technology, periodontal ligament stem cells (PDLSCs) has become one of the hot research topics. When PDLSCs was co-cultured with different cells, the mechanism of immune regulation and oriented differentiation could be studied. In the periodontal tissue engineering, it could provide support for the discovery of tissue repair materials. So this paper makes a brief review of the application of cell co-culture technique in PDLSCs research at present. |
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