| 肖 岚,李江涛,李 强,李明涵,陈 芍.非布司他对急性痛风性关节炎患者血清SUA水平及氧化应激的影响[J].,2018,(8):1548-1551 |
| 非布司他对急性痛风性关节炎患者血清SUA水平及氧化应激的影响 |
| Effect of Febuxostat on the Level of Serum UA and Oxidative Stress in Patients with Acute Gouty Arthritis |
| 投稿时间：2017-06-27 修订日期：2017-07-21 |
| DOI：10.13241/j.cnki.pmb.2018.08.031 |
| 中文关键词: 非布司他 急性痛风性关节炎 疗效 血清尿酸 氧化应激 |
| 英文关键词: Febuxostat Acute gouty arthritis Curative effect SUA Oxidative stress |
| 基金项目:四川省卫生计生委科研基金项目（16PJ124） |
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| 中文摘要: |
| 摘要 目的：研究非布司他治疗急性痛风性关节炎(AGA)患者的临床疗效及对血清尿酸(SUA)水平及氧化应激的影响。方法：研究对象选取我院2014年6月到2016年10月收治的200例AGA患者，采用随机数字法将其分为对照组和观察组，每组各100例。对照组患者口服别嘌呤醇治疗，观察组患者口服非布司他治疗，均连续治疗24周。比较两组患者治疗前后各时间点的血清SUA、8-羟基脱氧鸟苷(8-OHdG)、3-硝基络氨酸修饰蛋白(3-NT)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平的变化。结果：治疗后，观察组各时间点的血清SUA、8-OHdG和3-NT水平均明显低于对照组(P<0.01)。治疗后，对照组患者的血清TG、TC、HDL、LDL水平较治疗前无明显变化(P>0.05)，观察组患者的血清TG水平明显低于治疗前(P<0.01)，血清HDL水平明显高于治疗前(P<0.01)，而血清TC和LDL水平比较无明显差异(P>0.05)。结论：非布司他治疗AGA的疗效明显，能有效降低血清SUA水平，抑制氧化应激状态，并能改善血脂代谢。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of febuxostat in the treatment of acute gouty arthritis (AGA) and the effect of on the serum uric acid (SUA) level and oxidative stress. Methods: 200 cases of AGA patients in our hospital from June 2014 to October 2016 were randomly divided into the control group and the observation group, with 100 cases in each group. The control group was treated with allopurinol, while the observation group was treated with febuxostat, both groups were treated for 24 weeks. The serum SUA levels, 8- hydroxydeoxyguanosine (8-OHdG), 3- nitro tyrosine modified protein (3-NT), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) before and after treatment at different time points were compared between two groups. Results: After treatment, the serum SUA, 8-OHdG and 3-NT levels in the observation group at each time points were significantly lower of than those of the control group(P<0.01), the serum TG, TC, HDL, LDL levels of control group showed no significant difference than those before treatment(P>0.05) the serum TG level of observation group was lower than that before treatment(P<0.01), while the serum HDL level was higher than that before treatment(P<0.01), serum TC, LDL levels showed no significant difference(P>0.05). Conclusion: Febuxostat could effectively reduce the level of serum SUA, inhibit the oxidative stress, and improve blood lipid metabolism in the treatment of patients with AGA. |
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