| 刘 毅,李 丽,程 磊,吴 琼,李炳生.基于模式生物斑马鱼Nrf2的相关研究进展[J].,2018,(6):1181-1184 |
| 基于模式生物斑马鱼Nrf2的相关研究进展 |
| Research Progress of Model Organism Zebrafish Nrf2 |
| 投稿时间：2017-03-30 修订日期：2017-04-23 |
| DOI：10.13241/j.cnki.pmb.2018.06.039 |
| 中文关键词: 斑马鱼 Nrf2 胚胎发育 氧化应激 Nrf2/ARE信号通路 |
| 英文关键词: Zebrafish Nrf2 Embryonic development Oxidative stress Nrf2 / ARE signal pathway |
| 基金项目:国家自然科学基金项目（11474076）；新教师基金项目(20132302120069)；农业部淡水水产生物技术与遗传育种重点实验室开放课题（FBB2015-03） |
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| 中文摘要: |
| 摘要：Nrf2/ARE信号通路是大多数生物体内抗氧化应激反应、抵抗内外界刺激的关键通路，在抗炎症、免疫、抗肿瘤、抗凋亡、神经保护等方面起着重要的作用。斑马鱼作为一种常见的模式动物，广泛地应用于发育生物学、遗传学和毒理学等研究领域。研究表明转录因子NF_E2相关因子2（NF-E2-related factor 2,Nrf2）不仅在哺乳动物体内存在，也在斑马鱼体内存在并且高度保守，并在抗氧化应激反应中发挥着重要作用。本文通过对斑马鱼Nrf2的结构、生物学功能及其信号通路等方面的最新研究进行阐述，以期为Nrf2及其信号通路引发的相关疾病的预防和治疗提供新的思路。 |
| 英文摘要: |
| ABSTRACT: The signal pathway of Nrf2 / ARE is the critical pathway of most organisms in antioxidant stress reaction and resistance to external stimuli. It plays an important role in anti-inflammatory, immune, anti-tumor, anti-apoptotic, nerve protection and other areas. As a common mode of animals, zebrafish is widely used in developmental biology, genetics, toxicology and other research fields. The research shows that the transcription factor NF_E2 related factor 2 not only exists in mammals, but also exists in zebrafish and it is highly conservative and plays an important role in antioxidant stress reaction. This article aims to describe the latest research progress on the structure and function and signal pathway of Nrf2, with the purpose of giving insights into the prevention and therapy of disease caused by Nrf2/ ARE signal pathway. |
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