| 李 宏,何 萌,黎 亮,丁 欢,麦 力.参芪扶正注射液联合地西他滨对急性髓系白血病患者血清HGF、VEGF与LDH水平的影响[J].,2018,(6):1085-1088 |
| 参芪扶正注射液联合地西他滨对急性髓系白血病患者血清HGF、VEGF与LDH水平的影响 |
| Effect of Shenqi Fuzheng Injection Combined with Decitabine on the Serum HGF, VEGF and LDH Levels of Patients with Acute Myeloid Leukemia |
| 投稿时间：2017-06-22 修订日期：2017-07-16 |
| DOI：10.13241/j.cnki.pmb.2018.06.017 |
| 中文关键词: 急性髓系白血病 地西他滨 参芪扶正注射液 肝细胞生长因子 血管内皮生长因子 乳酸脱氢酶 |
| 英文关键词: Acute myeloid leukemia Decitabine Shenqi Fuzheng Injection Hepatocyte growth factor Vascular endothelial growth factor Lactate dehydrogenase |
| 基金项目:重庆市自然科学基金项目(20082207） |
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| 中文摘要: |
| 摘要 目的：探讨参芪扶正注射液联合地西他滨对急性髓系白血病患者血清肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)与乳酸脱氢酶(LDH)水平的影响。方法：选择2014年8月至2016年8月我院接诊的84例急性髓系白血病患者，通过随机数表法分为观察组(n=42)和对照组(n=42)。对照组给予地西他滨+DA化疗方案(柔红霉素+阿糖胞苷)，观察组联合参芪扶正注射液，两组均以21d为1个周期，连续治疗2个周期。比较两组治疗前后血常规、血清HGF、VEGF和LDH水平的变化、临床疗效及不良反应的发生情况。结果：治疗后，两组血常规、血清HGF、VEGF和LDH水平均较治疗前显著改善(P＜0.05)；观察组白细胞计数(WBC)明显低于对照组，血红蛋白(HGB)、血小板计数(PLT)、中性粒细胞计数(NEU)水平明显高于对照组(P＜0.05)；观察组临床疗效总缓解率明显高于对照组(P＜0.05)；观察组恶心呕吐、感染、多汗、出血、心脏毒性发生率均明显低于对照组(P＜0.05)。结论：应用参芪扶正注射液联合地西他滨治疗急性髓系白血病患者的临床效果显著，有助于降低毒副反应，其内在机制可能和降低血清HGF、VEGF、LDH的水平相关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of shenqi fuzheng injection combined with decitabine on the acute myeloid leukemia and its effects on hepatocyte growth factor(HGF), vascular endothelial growth factor(VEGF) and lactate dehydrogenase(LDH). Methods: 84 patients of acute myeloid leukemia who received therapy from August 2014 to August 2016 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=42) and the control group (n=42). The control group was treated with decitabine+ DA chemotherapy regimen(Daunorubicin + cytarabine), while the observation group was combined with shenqi fuzheng injection, both groups were treated with 21d for 1 cycles, continuous treatment for 2 cycles. The changes of blood routine, serum HGF, VEGF and LDH levels before and after treatment and the clinical efficacy and incidence of adverse reactions were compared between the two groups. Results: After treatment, the routine blood routine, serum HGF, VEGF and LDH levels of the two groups were significantly improved(P＜0.05); the white blood count (WBC) of observation group was significantly lower than that of the control group, and the hemoglobin (HGB), platelet count (PLT) and neutrophil count (NEU) were significantly higher than that of the control group(P＜0.05); the total remission rate of clinical efficacy of observation group were significantly higher than that of the control group(P＜0.05); the incidence of nausea and vomiting, infected, hyperhidrosis, hemorrhage, cardiotoxicity in the observation group were significantly lower than those of the control group(P＜0.05). Conclusion: Shenqi fuzheng injection combined with decitabine is effective for acute myeloid leukemia, which can improve the clinical efficacy and reduce the toxic and side effects, and it’s intrinsic mechanism may be related to the decrease of serum HGF, VEGF and LDH levels. |
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