| 张 琴,杨 磊,欧阳林旗,胡炜航,李聪杰.银杏达莫联合通痹胶囊治疗冠心病心绞痛的临床疗效及对血清IL-1β、TNF-α、ET-1、MMP-9水平的影响[J].,2018,(5):915-918 |
| 银杏达莫联合通痹胶囊治疗冠心病心绞痛的临床疗效及对血清IL-1β、TNF-α、ET-1、MMP-9水平的影响 |
| Clinical Efficacy of Ginkgo Biloba and Tongbi Capsule in Treating Angina Pectoris and Its Effects on the Serum IL-1β, TNF-α, ET-1 and MMP-9 Levels |
| 投稿时间：2017-05-30 修订日期：2017-06-25 |
| DOI：10.13241/j.cnki.pmb.2018.05.025 |
| 中文关键词: 银杏达莫 通痹胶囊 冠心病 心绞痛 |
| 英文关键词: Ginkgo biloba Tongbi capsule Coronary heart disease Angina pectoris |
| 基金项目:湖南省科技基本建设投资计划项目(2013HS02355) |
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| 中文摘要: |
| 摘要 目的：研究银杏达莫联合通痹胶囊治疗冠心病心绞痛的临床疗效及对血清白细胞介素-1β( IL-1β)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9)水平的影响。方法：选取2015年8月至2016年7月我院收治的84例冠心病心绞痛患者，根据患者入院顺序分为观察组和对照组，42例每组。对照组使用通痹胶囊完成治疗，观察组在此基础上联合银杏达莫完成治疗。比较两组患者临床疗效、心绞痛发作次数、持续时间、ST段下移程度、血清IL-1β、TNF-α、ET-1、MMP-9水平的变化。结果：治疗后，观察组临床总有效率显著高于对照组[92.86%(39/42)比66.67%(28/42)](P<0.05)；两组患者心绞痛发作次数、持续时间、ST段下移程度、血清IL-1β、TNF-α、ET-1、MMP-9水平均较治疗前显著降低(P<0.05)，且观察组以上指标均明显低于对照组(P<0.05)。观察组和对照组的不良反应发生率比较差异无统计学意义(P>0.05)。结论：银杏达莫联合通痹胶囊治疗冠心病心绞痛能有效改善患者临床症状并提高临床疗效，可能与其显著降低患者血清IL-1β、TNF-α、ET-1、MMP-9水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of ginkgo biloba combined with Tongbi capsule in the treatment of angina pectoris and its effect on the serum interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), endothelin-1(ET-1) and matrix metallopro- tein-9(MMP-9) levels. Methods: From August 2015 to July 2016, 84 patients with angina pectoris in our hospital were selected and di- vided into the observation group and the control group according to the order of admission. The control group was treated with Tongbi Capsule, and the observation group was treated with Ginkgo biloba. The clinical efficacy, clinical symptoms, serum IL-1β, TNF-α, ET-1 and MMP-9 levels were compared between the two groups. Results: After treatment, the total effective rate of observation group was sig- nificantly higher than that of the control group [92.86% (39/42) vs 66.67% (28/42)] (P<0.05). The times of angina pectoris, duration and ST segment depression showed no difference between two groups before treatment (P>0.05). After treatment, the number of episodes and duration and ST segment depression were significantly lower than those before treatment in the two groups (P<0.05). Compared with the control group, the number of angina pectoris, duration, ST segment depression were lower(P<0.05). There was no significant difference in the serum IL-1β, TNF-α, ET-1 and MMP-9 levels between the two groups before treatment (P>0.05). After treat- ment, IL-1β, TNF-α, ET-1, MMP-9 were lower than before treatment(P<0.05). Compared with the control group, the levels of IL-1β, TNF-α, ET-1 and MMP-9 in the observation group were lower after treatment(P<0.05). There was no significant difference in the inci- dence of adverse re- action between two groups(P>0.05). Conclusion: Ginkgo biloba and Tongbi Capsule could effectively improve the serum levels of IL-1β, TNF-α, ET-1 and MMP-9 of patients with angina pectoris and improve the clinical symptoms. |
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