| 石海平,黄 伟,罗 可,熊学华,张庭荣.神经内镜辅助下经鼻蝶窦入路术对垂体瘤患者血清E, NE, R及ATⅡ的影响及其临床疗效[J].,2018,(2):289-292 |
| 神经内镜辅助下经鼻蝶窦入路术对垂体瘤患者血清E, NE, R及ATⅡ的影响及其临床疗效 |
| Effects of Transnasal Endoscopic Endonasal Transsphenoidal Approach on Serum Levels of E, NE, R and ATⅡ in Patients with Hypophysoma and Its Clinical Efficacy |
| 投稿时间：2017-07-17 修订日期：2017-08-10 |
| DOI：10.13241/j.cnki.pmb.2018.02.021 |
| 中文关键词: 神经内镜辅助 经鼻蝶窦入路术 垂体瘤 应激反应 |
| 英文关键词: Neuroendoscope Transsphenoidal approach Hypophysoma Stress reaction |
| 基金项目:四川省卫生厅科研基金项目（080411） |
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| 中文摘要: |
| 摘要 目的：研究神经内镜辅助下经鼻蝶窦入路术对垂体瘤的临床观察及对肾上腺素（epinephrine, E）、去甲肾上腺素（Norepinephrine, NE）、肾素（Renin, R）、血管紧张素（Angiotensin, ATⅡ）的影响。方法：收集2015年3月-2017年3月我院收治的60例垂体瘤患者，随机分为实验组和对照组，每组30例，实验组采用神经内镜辅助下经鼻蝶窦入路术治疗，对照组采用经口鼻下鼻中隔垂体瘤切除术治疗。观察并比较两组治疗疗效，手术时间、术中出血量、住院时间，血清E、NE、R及ATⅡ水平，激素下降程度、肿瘤残留、肿瘤体积减少程度、复发率及不良反应。结果：实验组总有效率显著高于对照组（P＜0.05）; 手术时间、术中出血量、住院时间均显著小于对照组（P＜0.05）；E、NE、R、ATⅡ水平显著低于对照组（P＜0.05）；激素下降程度、肿瘤残留、肿瘤体积减少程度、复发率显著低于对照组（P＜0.05）；不良反应总发生率显著低于对照组（P＜0.05）。结论：神经内镜辅助下经鼻蝶窦入路术对垂体瘤的疗效显著，可减少应激反应，提高肿瘤全切除率，可减少术后并发症，利于患者预后。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of endoscopic endonasal transsphenoidal approach in treatment of hypophysoma and its effects on serum levels of E (epinephrine), NE (Norepinephrine), R (Renin) and ATⅡ(Angiotensin). Methods: 60 patients with hypophysoma who received therapy from March 2015 to March 2017 in our hospital were selected and randomly divided into the experimental group and the control group, with 30 cases in each group. The patients in the control group were treated with transnasal endoscopic endonasal transsphenoidal approach, while the patients in the experimental group were treated with resection of pituitary adenoma by nasal septum. Then the curative effect, operation time, intraoperative blood loss, hospitalization, serum levels of E, NE, R and AT II, the degree of hormone decline, tumor residue, tumor volume reduction, recurrence rate and the adverse reactions in the two groups were observed and compared before and after the treatment. Results: The total effective rate of the experimental group was significantly higher than that of the control group (P＜0.05); The operation time, blood loss and the length of stay of the experimental group were significantly lower than those of the control group (P＜0.05); The serum levels of E, NE, R and ATⅡ of the experimental group were significantly lower than those of the control group (P＜0.05); The degree of hormone decrease, tumor residue, tumor volume decrease and recurrence rate of the experimental group were significantly lower than those of the control group (P＜0.05); The incidence of adverse reactions of the experimental group was significantly lower than that of the control group (P＜0.05). Conclusion: Transnasal endoscopic endonasal transsphenoidal approach has better efficacy of hypophysoma, which can reduce the stress reaction and postoperative complications, improve the total resection rate of the tumor, and remarkably improve the curative effect. |
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