| 郝秋亚,肖 巍,张夏华,江煜晗,李亚娟,郝彦兰.CXCR4和NF-κB在子宫内膜癌中的表达及其临床意义[J].,2018,(1):90-94 |
| CXCR4和NF-κB在子宫内膜癌中的表达及其临床意义 |
| Expression of CXCR4 and NF-κB in Endometrial Carcinoma and their Clinical Significance |
| 投稿时间：2017-05-13 修订日期：2017-05-30 |
| DOI：10.13241/j.cnki.pmb.2018.01.020 |
| 中文关键词: CXCR4 NF-κB 子宫内膜癌 免疫组织化学 |
| 英文关键词: CXC chemokine receptor 4 Nuclear factor-kappaB Endometrial carcinoma Immuno-histochemistry |
| 基金项目:黑龙江省自然科学基金项目（201429） |
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| 中文摘要: |
| 摘要 目的：检测CXCR4和NF-κB在子宫内膜癌中的表达并探讨其在肿瘤发生发展中的作用机制。方法：用免疫组织化学SP法测定不同子宫内膜组织中CXCR4和NF-κB的蛋白质表达情况，并分析两者表达的相关性，所选标本包括20 例正常子宫内膜蜡块、30例子宫内膜不典型增生石蜡标本、60例子宫内膜癌。结果：CXCR4的阳性表达率在子宫内膜癌中为73.33 %、在不典型增生子宫内膜中为43.33 %，在正常子宫内膜中为25.00 %；NF-κB 在子宫内膜癌、不典型增生子宫内膜和正常子宫内膜的阳性表达率依次为：63.33 %、36.67 %、15.00 %，差异均具有统计学意义(P<0.05)。CXCR4和NF-κB两个因子与淋巴结有无转移、年龄、肌层浸润情况无相关性，但与癌组织分化级别相关。两个因子在子宫内膜癌中的表达具有明显的相关性(r=0.341，P=0.008)。结论：CXCR4和NF-κB在子宫内膜癌组中的阳性表达率明显升高，且两者成正相关，两个因子在诱发子宫内膜癌的发生中可能起协同作用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression and clinical significance of CXCR4 and NF-κB in endometrial carcinoma. Methods: 20 cases of normal endometrium tissues, 30 cases of endometrial atypical hyperplasia tissues, and 60 cases of endometrial cancer tis- sues were selected as the research objects, and the protein expression of CXCR4 and NF-κB was detected with immunohistochemical technique in different tissues, and the correlation of CXCR4 and NF-κB expression was analyzed. Results: The positive expression rate of CXCR4 in endometrial carcinoma, endometrial atypical hyperplasia, normal endometium was 73.33 %, 43.33 %, 25.00 % respectively, and the positive expression rate of NF-κB was 63.33 % in endometrial carcinoma, 36.67 % in atypical hyperplasia of endometrium, and 15.00 % in normal endometrium tissues and the difference of their expression was dramaticlly statistically significant among groups (P＜0.05). The expression of CXCR4 and NF-κB was independent from lymph node metastasis, age, and myometrial invasion, but had corre- lation with differentiation of tumor. In addtion, there was positive correlation between them. Conclusion: The expression of CXCR4 and NF-κB is elevated obviously in endometrial carcinoma tissues, and they are positively related, suggesting that a vital important role in the progress of endometrial carcinoma. |
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