| 马丙涛,乔 林,郝国兵,王奎友,张树明.玻璃酸钠联合臭氧关节腔内注射对创伤性踝关节炎患者血清hs-CRP、IL-1β、IL-6和TNF-α水平的影响[J].,2017,17(36):7072-7075 |
| 玻璃酸钠联合臭氧关节腔内注射对创伤性踝关节炎患者血清hs-CRP、IL-1β、IL-6和TNF-α水平的影响 |
| Effect of Sodium Hyaluronate Combined with Ozone Intra-articular Injection on the Serum Levels of hs-CRP, IL-1β, IL-6 and TNF-α of Patients with Traumatic Ankle Arthritis |
| 投稿时间：2017-03-13 修订日期：2017-04-10 |
| DOI：10.13241/j.cnki.pmb.2017.36.016 |
| 中文关键词: 创伤性踝关节炎 玻璃酸钠 臭氧 血清超敏C反应蛋白(hs-CRP) 白介素(IL)-1β 白介素-6 肿瘤坏死因子(TNF)-α |
| 英文关键词: Traumatic ankle arthritis Sodium hyaluronate Ozone hs-CRP IL-1β IL-6 TNF-α |
| 基金项目:北京市自然科学基金项目(7112143) |
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| 中文摘要: |
| 摘要 目的：探讨玻璃酸钠联合臭氧关节腔内注射对创伤性踝关节炎患者血清超敏C反应蛋白(hs-CRP)、白介素(IL)-1β、IL-6和肿瘤坏死因子(TNF)-α水平的影响。方法：选择2013年1月至2016年8月我院接诊的92例创伤性踝关节炎患者作为本次研究对象，通过随机数表法分为观察组(n=46)和对照组(n=46)。对照组在关节腔给注射玻璃酸钠治疗，观察组联合臭氧治疗，均1次/周，连续治疗5次。比较两组治疗前后视觉模拟评分法(VAS)、McGuire踝关节评分以及血清hs-CRP、IL-1β、IL-6和TNF-α的变化及治疗后临床疗效优良率。结果：治疗前，两组VAS评分、McGuire踝关节评分、血清hs-CRP、IL-1β、IL-6和TNF-α水平比较差异均无统计学意义(P＞0.05)。治疗后，两组VAS评分、McGuire踝关节评分均较治疗前显著改善(P＜0.05)，且观察组VAS评分明显低于对照组，McGuire踝关节评分明显高于对照组(P＜0.05)；两组血清hs-CRP、IL-1β、IL-6和TNF-α水平较治疗前均显著降低(P＜0.05)，且观察组血清hs-CRP、IL-1β、IL-6和TNF-α比较均明显低于对照组(P＜0.05)；观察组临床疗效优良率明显高于对照组(P＜0.05)。结论：关节腔内注射玻璃酸钠联合臭氧治疗创伤性踝关节炎患者的临床效果优于单用关节腔注射玻璃酸钠，可有效缓解疼痛，改善关节功能，可能与其有效降低血清hs-CRP、IL-1β、IL-6和TNF-α水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the effect of sodium hyaluronate combined with ozone intra-articular injection on the serum levels of high sensitivity C reactive protein(hs-CRP), interleukin(IL)-1β, IL-6 and tumor necrosis factor(TNF)-α of patients with traumatic an- kle arthritis. Methods: 92 patients of traumatic ankle arthritis who were treated from January 2013 to August 2016 in our hospital were selected as the research object. According to random number table, those patients were divided into the observation group (n=46) and the control group (n=46). The control group was treated with intra-articular injection of sodium hyaluronate, while the observation group was combined with ozone. The changes of visual analogue scale (VAS), McGuire ankle score and serum hs-CRP, IL-1β, IL-6 and TNF-α before and after treatment as well as the excellent and good rate were compared between two groups. Results: Before treatment, there was no significant difference between the two groups in VAS score, McGuire ankle score, no significant difference was found in the serum hs-CRP, IL-1β, IL-6 and TNF-α levls between two groups(P＞0.05). After treatment, the VAS score and McGuire ankle score of both groups were significantly improved compared with those before treatment(P＜0.05), the VAS score in the observation group was significantly lower than that of the control group, and the McGuire ankle score was significantly higher than that of the control group(P＜0.05); the serum levels of hs-CRP, IL-1β, IL-6 and TNF-α were significantly lower than those before treatment(P＜0.05), the serum hs-CRP, IL-1β, IL-6 and TNF-α levels in the observation group were significantly lower than those of the control group(P＜0.05); the excellent and good rate of observation group was significantly higher than that of the control group(P＜0.05). Conclusion: Sodium hyaluronate combined with ozone intra-articular injection was effective for the traumatic ankle arthritis, which could effectively relieve the pain and improve the joint function, it might be related to the reduce of serum hs-CRP, IL-1β, IL-6 and TNF-α levels. |
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