| 张璐璐,陈 亮,杜 丽,叶学嫦,曾宗鼎.乌司他丁联合参麦注射液治疗创伤后早期急性肺损伤疗效及对血清TNF-α、IL-6水平的影响[J].,2017,17(33):6540-6543 |
| 乌司他丁联合参麦注射液治疗创伤后早期急性肺损伤疗效及对血清TNF-α、IL-6水平的影响 |
| Effect of Ulinastatin combined with Shenmai Injection on Early Acute Lung Injury after Trauma |
| 投稿时间：2017-05-01 修订日期：2017-05-23 |
| DOI：10.13241/j.cnki.pmb.2017.33.032 |
| 中文关键词: 乌司他丁 参麦注射液 创伤 早期急性肺损伤 TNF-α IL-6 |
| 英文关键词: Ulinastatin Shenmai injection Trauma Early acute lung injury TNF-α IL-6 |
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| 中文摘要: |
| 摘要 目的：探讨乌司他丁联合参麦注射液治疗创伤后早期急性肺损伤疗效及对血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）水平的影响。方法：收集我院于2012年6月~2016年6月间收治的创伤后早期急性肺损伤（ALI）患者200例。通过随机数表法分为常规组及实验组各100例，常规组患者给予常规西医方案治疗，实验组患者在常规组治疗方案的基础上加用乌司他丁及参麦注射液联合治疗。统计比较两组患者临床疗效，重症监护室（ICU）天数、住院总天数及急性呼吸窘迫综合征（ARDS）发生率；检测两组患者治疗前后血气分析指标变化；采用酶联免疫吸附实验（ELISA）于治疗前、治疗1 d后、治疗3 d后、治疗7 d后检测两组患者血清TNF-α、IL-6水平。结果：实验组疗效总有效率为88.00%，明显高于常规组的75.00%，差异有统计学意义（P<0.05）。实验组ICU天数及住院总天数、ARDS发生率均低于常规组，差异均有统计学意义（P<0.05）。实验组患者治疗后动脉氧分压（PaO2）、氧合指数（PaO2/FIO2）后水平均高于常规组，差异有统计学意义（P<0.05）。实验组患者治疗3 d后、治疗7 d后血清TNF-α、IL-6水平均低于常规组，差异有统计学意义（P<0.05）。结论：采用乌司他丁联合参麦注射液治疗ALI患者疗效显著，可有效降低组织氧化应激损伤，改善肺部微循环功能，降低ICU时间及住院时间，改善ALI患者肺氧合功能，降低血清TNF-α和IL-6水平。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of ulinastatin combined with Shenmai injection in the treatment of early acute lung injury (ALI) after trauma and its influence on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels. Methods: A total of 200 patients with early ALI after trauma, who were admitted to Nongken Sanya Hospital of Hainan Province from June 2012 to June 2016, were collected and randomly divided into conventional group(n=100) and experimental group(n=100). The conventional group was given conventional western medicine treatment, while the experimental group was added ulinastatin and Shenmai injection on the basis of the treatment of conventional group. The clinical efficacy, intensive care unit (ICU) days, total length of stay in hospital and the inci- dence of acute respiratory distress syndrome (ARDS) of the two groups were compared. The blood gas indexes of the two groups before and after treatment were detected; and the levels of serum TNF-α and IL-6 of the two groups before treatment and 1 d, 3 d, and 7 d after treatment were detected by enzyme linked immunosorbent assay method. Results: The total effective rate(88.00%) of the experimental group was significantly higher than that(75.00%) of the conventional group,the difference was statistically significant (P<0.05). The ICU days, total length of stay in hospital and the incidence of ARDS in the experimental group were lower than those in the conventional group, the differences were statistically significant (P<0.05). The partial pressure of artery(PaO2) and oxygenation index (PaO2/FIO2) in the experimental group were higher than those in the conventional group, the differences were statistically significant (P<0.05). The levels of serum TNF-α and IL-6 in the experimental group were lower than those in the conventional group 3 d and 7 d after treatment, the dif- ferences were statistically significant (P<0.05). Conclusion: Ulinastatin combined with Shenmai injection has a good clinical efficacy in the treatment of early ALI after trauma, which can effectively reduce oxidative stress, improve pulmonary microcirculation and cut down the duration in ICU and hospital, improve pulmonary oxygenation function, and reduce the serum TNF-α and IL-6 levels. |
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